Nickel-Catalyzed Direct C (sp<sup>3</sup>)–H Arylation of Aliphatic Amides with Thiophenes Xie Wang Longzhi Zhu Sihai Chen Xinhua Xu Chak-Tong Au Renhua Qiu 10.1021/acs.orglett.5b02572.s001 https://acs.figshare.com/articles/journal_contribution/Nickel_Catalyzed_Direct_C_sp_sup_3_sup_H_Arylation_of_Aliphatic_Amides_with_Thiophenes/2112241 Nickel-catalyzed heteroarylation of the inactive methyl C­(sp<sup>3</sup>)–H bond of aliphatic amide with heteroarenes is described. The method takes advantage of chelation assistance by an 8-aminoquinolinyl moiety. The synthetic reaction has good tolerance toward functional groups, and it can be used in the construction of various kinds of alkyl-substituted heteroarenes. 2015-11-06 00:00:00 aminoquinolinyl heteroarene moiety Arylation aliphatic amide heteroarylation tolerance method Aliphatic Amides methyl chelation assistance kind sp construction bond