Nickel-Catalyzed Direct C (sp<sup>3</sup>)–H
Arylation of Aliphatic Amides with Thiophenes
Xie Wang
Longzhi Zhu
Sihai Chen
Xinhua Xu
Chak-Tong Au
Renhua Qiu
10.1021/acs.orglett.5b02572.s001
https://acs.figshare.com/articles/journal_contribution/Nickel_Catalyzed_Direct_C_sp_sup_3_sup_H_Arylation_of_Aliphatic_Amides_with_Thiophenes/2112241
Nickel-catalyzed
heteroarylation of the inactive methyl C(sp<sup>3</sup>)–H
bond of aliphatic amide with heteroarenes is described.
The method takes advantage of chelation assistance by an 8-aminoquinolinyl
moiety. The synthetic reaction has good tolerance toward functional
groups, and it can be used in the construction of various kinds of
alkyl-substituted heteroarenes.
2015-11-06 00:00:00
aminoquinolinyl
heteroarene
moiety
Arylation
aliphatic amide
heteroarylation
tolerance
method
Aliphatic Amides
methyl
chelation assistance
kind
sp
construction
bond