TY - DATA T1 - Synthesis of Polysubstituted Pyridines via a One-Pot Metal-Free Strategy PY - 2015/12/18 AU - Hongbo Wei AU - Yun Li AU - Ke Xiao AU - Bin Cheng AU - Huifei Wang AU - Lin Hu AU - Hongbin Zhai UR - https://acs.figshare.com/articles/journal_contribution/Synthesis_of_Polysubstituted_Pyridines_via_a_One_Pot_Metal_Free_Strategy/2097571 DO - 10.1021/acs.orglett.5b02903.s001 L4 - https://ndownloader.figshare.com/files/3730813 KW - electrocyclization KW - Polysubstituted Pyridines KW - cascade reaction KW - Staudinger reaction KW - Wittig reaction KW - strategy KW - access KW - aldehyde KW - azatriene KW - synthesis KW - phosphorus ylides KW - polysubstituted pyridines KW - StrategyAn KW - substrate KW - shift KW - yield KW - propargyl azide KW - Synthesi KW - reaction sequence N2 - An efficient strategy for the one-pot synthesis of polysubstituted pyridines via a cascade reaction from aldehydes, phosphorus ylides, and propargyl azide is reported. The reaction sequence involves a Wittig reaction, a Staudinger reaction, an aza-Wittig reaction, a 6π-3-azatriene electrocyclization, and a 1,3-H shift. This protocol provides quick access to the polysubstituted pyridines from readily available substrates in good to excellent yields. ER -