Synthesis of Polysubstituted Pyridines via a One-Pot Metal-Free Strategy Hongbo Wei Yun Li Ke Xiao Bin Cheng Huifei Wang Lin Hu Hongbin Zhai 10.1021/acs.orglett.5b02903.s001 https://acs.figshare.com/articles/journal_contribution/Synthesis_of_Polysubstituted_Pyridines_via_a_One_Pot_Metal_Free_Strategy/2097571 An efficient strategy for the one-pot synthesis of polysubstituted pyridines via a cascade reaction from aldehydes, phosphorus ylides, and propargyl azide is reported. The reaction sequence involves a Wittig reaction, a Staudinger reaction, an aza-Wittig reaction, a 6π-3-azatriene electrocyclization, and a 1,3-H shift. This protocol provides quick access to the polysubstituted pyridines from readily available substrates in good to excellent yields. 2015-12-18 00:00:00 electrocyclization Polysubstituted Pyridines cascade reaction Staudinger reaction Wittig reaction strategy access aldehyde azatriene synthesis phosphorus ylides polysubstituted pyridines StrategyAn substrate shift yield propargyl azide Synthesi reaction sequence