NHC-Ag(I)-Catalyzed
Three-Component 1,3-Dipolar Cycloaddition
To Provide Polysubstituted Dihydro-/Tetrahydrofurans
Yi-Fei Liu
Zhen Wang
Jin-Wei Shi
Bai-Ling Chen
Zhi-Gang Zhao
Zili Chen
10.1021/acs.joc.5b02422.s002
https://acs.figshare.com/articles/dataset/NHC_Ag_I_Catalyzed_Three_Component_1_3_Dipolar_Cycloaddition_To_Provide_Polysubstituted_Dihydro_Tetrahydrofurans/2097517
A new
method was developed to synthesize polyfunctionalized dihydrofuran
and tetrahydrofuran derivatives from the three-component [2 + 2 +
1] cycloaddition of the diazoesters with aryl/alkenyl aldehydes and
alkyne/olefin dipolarophiles by using a Ag(I) <i>N</i>-heterocyclic
carbene complex as the catalyst. A carbonyl ylide intermediate was
generated, which undertook an <i>endo</i>-type 1,3-dipolar
cycloaddition to provide the desired dihydro-/tetrahydrofurans in
high regio- and diastereoselectivities by using α-aryl or α-alkenyl
diazoesters.
2015-12-18 00:00:00
Dipolar
Polysubstituted
cycloaddition
diastereoselectivitie
aldehyde
dipolar
method
polyfunctionalized dihydrofuran
dipolarophile
diazoester
tetrahydrofuran derivatives
regio
carbene
alkenyl
Dihydro
carbonyl ylide
Ag
alkyne
aryl
Cycloaddition
catalyst