NHC-Ag(I)-Catalyzed Three-Component 1,3-Dipolar Cycloaddition To Provide Polysubstituted Dihydro-/Tetrahydrofurans Yi-Fei Liu Zhen Wang Jin-Wei Shi Bai-Ling Chen Zhi-Gang Zhao Zili Chen 10.1021/acs.joc.5b02422.s002 https://acs.figshare.com/articles/dataset/NHC_Ag_I_Catalyzed_Three_Component_1_3_Dipolar_Cycloaddition_To_Provide_Polysubstituted_Dihydro_Tetrahydrofurans/2097517 A new method was developed to synthesize polyfunctionalized dihydrofuran and tetrahydrofuran derivatives from the three-component [2 + 2 + 1] cycloaddition of the diazoesters with aryl/alkenyl aldehydes and alkyne/olefin dipolarophiles by using a Ag­(I) <i>N</i>-heterocyclic carbene complex as the catalyst. A carbonyl ylide intermediate was generated, which undertook an <i>endo</i>-type 1,3-dipolar cycloaddition to provide the desired dihydro-/tetrahydrofurans in high regio- and diastereoselectivities by using α-aryl or α-alkenyl diazoesters. 2015-12-18 00:00:00 Dipolar Polysubstituted cycloaddition diastereoselectivitie aldehyde dipolar method polyfunctionalized dihydrofuran dipolarophile diazoester tetrahydrofuran derivatives regio carbene alkenyl Dihydro carbonyl ylide Ag alkyne aryl Cycloaddition catalyst