Zhang, Chen Wang, Shu Zeng, Ke-Wu Li, Jun Ferreira, Daneel Zjawiony, Jordan K. Liu, Bing-Yu Guo, Xiao-Yu Jin, Hong-Wei Jiang, Yong Tu, Peng-Fei Nitric Oxide Inhibitory Dimeric Sesquiterpenoids from <i>Artemisia rupestris</i> Twelve new dimeric sesquiterpenoids (<b>1</b>–<b>12</b>) were isolated from the dried whole plants of <i>Artemisia rupestris</i>. Their structures were determined using MS and NMR data, and the absolute configurations were elucidated on the basis of experimental and calculated ECD spectra. Compounds <b>1</b>–<b>9</b> are presumably formed via biocatalyzed [2+2] or [4+2] cycloaddition reactions. Stereoselectivity of the [4+2] Diels–Alder reaction dictated the formation of <i>endo</i>-products. The dimeric sesquiterpenoids exhibited moderate inhibition on NO production stimulated by lipopolysaccharide in BV-2 microglial cells, with IC<sub>50</sub> values in the range 17.0–71.8 μM. BV;microglial;cycloaddition;basis;lipopolysaccharide;inhibition;Stereoselectivity;Compound;Diel;Artemisia rupestris;NMR data;Artemisia rupestrisTwelve;formation;configuration;dimeric sesquiterpenoids;ECD spectra;Nitric Oxide Inhibitory Dimeric Sesquiterpenoids;IC 50 values;MS;biocatalyzed 2016-01-22
    https://acs.figshare.com/articles/journal_contribution/Nitric_Oxide_Inhibitory_Dimeric_Sesquiterpenoids_from_i_Artemisia_rupestris_i_/2084644
10.1021/acs.jnatprod.5b00894.s001