TY - DATA T1 - Nitric Oxide Inhibitory Dimeric Sesquiterpenoids from Artemisia rupestris PY - 2016/01/22 AU - Chen Zhang AU - Shu Wang AU - Ke-Wu Zeng AU - Jun Li AU - Daneel Ferreira AU - Jordan K. Zjawiony AU - Bing-Yu Liu AU - Xiao-Yu Guo AU - Hong-Wei Jin AU - Yong Jiang AU - Peng-Fei Tu UR - https://acs.figshare.com/articles/journal_contribution/Nitric_Oxide_Inhibitory_Dimeric_Sesquiterpenoids_from_i_Artemisia_rupestris_i_/2084644 DO - 10.1021/acs.jnatprod.5b00894.s001 L4 - https://ndownloader.figshare.com/files/3717844 KW - BV KW - microglial KW - cycloaddition KW - basis KW - lipopolysaccharide KW - inhibition KW - Stereoselectivity KW - Compound KW - Diel KW - Artemisia rupestris KW - NMR data KW - Artemisia rupestrisTwelve KW - formation KW - configuration KW - dimeric sesquiterpenoids KW - ECD spectra KW - Nitric Oxide Inhibitory Dimeric Sesquiterpenoids KW - IC 50 values KW - MS KW - biocatalyzed N2 - Twelve new dimeric sesquiterpenoids (1–12) were isolated from the dried whole plants of Artemisia rupestris. Their structures were determined using MS and NMR data, and the absolute configurations were elucidated on the basis of experimental and calculated ECD spectra. Compounds 1–9 are presumably formed via biocatalyzed [2+2] or [4+2] cycloaddition reactions. Stereoselectivity of the [4+2] Diels–Alder reaction dictated the formation of endo-products. The dimeric sesquiterpenoids exhibited moderate inhibition on NO production stimulated by lipopolysaccharide in BV-2 microglial cells, with IC50 values in the range 17.0–71.8 μM. ER -