Nitric Oxide Inhibitory Dimeric Sesquiterpenoids from <i>Artemisia rupestris</i> Chen Zhang Shu Wang Ke-Wu Zeng Jun Li Daneel Ferreira Jordan K. Zjawiony Bing-Yu Liu Xiao-Yu Guo Hong-Wei Jin Yong Jiang Peng-Fei Tu 10.1021/acs.jnatprod.5b00894.s001 https://acs.figshare.com/articles/journal_contribution/Nitric_Oxide_Inhibitory_Dimeric_Sesquiterpenoids_from_i_Artemisia_rupestris_i_/2084644 Twelve new dimeric sesquiterpenoids (<b>1</b>–<b>12</b>) were isolated from the dried whole plants of <i>Artemisia rupestris</i>. Their structures were determined using MS and NMR data, and the absolute configurations were elucidated on the basis of experimental and calculated ECD spectra. Compounds <b>1</b>–<b>9</b> are presumably formed via biocatalyzed [2+2] or [4+2] cycloaddition reactions. Stereoselectivity of the [4+2] Diels–Alder reaction dictated the formation of <i>endo</i>-products. The dimeric sesquiterpenoids exhibited moderate inhibition on NO production stimulated by lipopolysaccharide in BV-2 microglial cells, with IC<sub>50</sub> values in the range 17.0–71.8 μM. 2016-01-22 00:00:00 BV microglial cycloaddition basis lipopolysaccharide inhibition Stereoselectivity Compound Diel Artemisia rupestris NMR data Artemisia rupestrisTwelve formation configuration dimeric sesquiterpenoids ECD spectra Nitric Oxide Inhibitory Dimeric Sesquiterpenoids IC 50 values MS biocatalyzed