Nitric Oxide Inhibitory Dimeric Sesquiterpenoids from <i>Artemisia rupestris</i>
Chen Zhang
Shu Wang
Ke-Wu Zeng
Jun Li
Daneel Ferreira
Jordan
K. Zjawiony
Bing-Yu Liu
Xiao-Yu Guo
Hong-Wei Jin
Yong Jiang
Peng-Fei Tu
10.1021/acs.jnatprod.5b00894.s001
https://acs.figshare.com/articles/journal_contribution/Nitric_Oxide_Inhibitory_Dimeric_Sesquiterpenoids_from_i_Artemisia_rupestris_i_/2084644
Twelve new dimeric sesquiterpenoids
(<b>1</b>–<b>12</b>) were isolated from the dried
whole plants of <i>Artemisia
rupestris</i>. Their structures were determined using MS and
NMR data, and the absolute configurations were elucidated on the basis
of experimental and calculated ECD spectra. Compounds <b>1</b>–<b>9</b> are presumably formed via biocatalyzed [2+2]
or [4+2] cycloaddition reactions. Stereoselectivity of the [4+2] Diels–Alder
reaction dictated the formation of <i>endo</i>-products.
The dimeric sesquiterpenoids exhibited moderate inhibition on NO production
stimulated by lipopolysaccharide in BV-2 microglial cells, with IC<sub>50</sub> values in the range 17.0–71.8 μM.
2016-01-22 00:00:00
BV
microglial
cycloaddition
basis
lipopolysaccharide
inhibition
Stereoselectivity
Compound
Diel
Artemisia rupestris
NMR data
Artemisia rupestrisTwelve
formation
configuration
dimeric sesquiterpenoids
ECD spectra
Nitric Oxide Inhibitory Dimeric Sesquiterpenoids
IC 50 values
MS
biocatalyzed