10.1021/acs.jnatprod.5b00894.s001
Chen Zhang
Chen
Zhang
Shu Wang
Shu
Wang
Ke-Wu Zeng
Ke-Wu
Zeng
Jun Li
Jun
Li
Daneel Ferreira
Daneel
Ferreira
Jordan
K. Zjawiony
Jordan
K.
Zjawiony
Bing-Yu Liu
Bing-Yu
Liu
Xiao-Yu Guo
Xiao-Yu
Guo
Hong-Wei Jin
Hong-Wei
Jin
Yong Jiang
Yong
Jiang
Peng-Fei Tu
Peng-Fei
Tu
Nitric Oxide Inhibitory Dimeric Sesquiterpenoids from <i>Artemisia rupestris</i>
American Chemical Society
2016
BV
microglial
cycloaddition
basis
lipopolysaccharide
inhibition
Stereoselectivity
Compound
Diel
Artemisia rupestris
NMR data
Artemisia rupestrisTwelve
formation
configuration
dimeric sesquiterpenoids
ECD spectra
Nitric Oxide Inhibitory Dimeric Sesquiterpenoids
IC 50 values
MS
biocatalyzed
2016-01-22 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Nitric_Oxide_Inhibitory_Dimeric_Sesquiterpenoids_from_i_Artemisia_rupestris_i_/2084644
Twelve new dimeric sesquiterpenoids
(<b>1</b>–<b>12</b>) were isolated from the dried
whole plants of <i>Artemisia
rupestris</i>. Their structures were determined using MS and
NMR data, and the absolute configurations were elucidated on the basis
of experimental and calculated ECD spectra. Compounds <b>1</b>–<b>9</b> are presumably formed via biocatalyzed [2+2]
or [4+2] cycloaddition reactions. Stereoselectivity of the [4+2] Diels–Alder
reaction dictated the formation of <i>endo</i>-products.
The dimeric sesquiterpenoids exhibited moderate inhibition on NO production
stimulated by lipopolysaccharide in BV-2 microglial cells, with IC<sub>50</sub> values in the range 17.0–71.8 μM.