Isoxazole Alters Metabolites and Gene Expression,
Decreasing Proliferation and Promoting a Neuroendocrine Phenotype
in β‑Cells
Michael
A. Kalwat
Zhimin Huang
Chonlarat Wichaidit
Kathleen McGlynn
Svetlana Earnest
Claudia Savoia
Elhadji
M. Dioum
Jay W. Schneider
Michele R. Hutchison
Melanie H. Cobb
10.1021/acschembio.5b00993.s006
https://acs.figshare.com/articles/dataset/Isoxazole_Alters_Metabolites_and_Gene_Expression_Decreasing_Proliferation_and_Promoting_a_Neuroendocrine_Phenotype_in_Cells/2081395
Novel strategies are needed to modulate
β-cell differentiation
and function as potential β-cell replacement or restorative
therapies for diabetes. We previously demonstrated that small molecules
based on the isoxazole scaffold drive neuroendocrine phenotypes. The
nature of the effects of isoxazole compounds on β-cells was
incompletely defined. We find that isoxazole induces genes that support
neuroendocrine and β-cell phenotypes and suppresses genes important
for proliferation. Isoxazole alters β-cell metabolites and protects
glucose-responsive signaling pathways under lipotoxic conditions.
Finally, we show that isoxazole improves glycemia in a mouse model
of β-cell regeneration. Isoxazole is a prime candidate to alter
cell fate in different contexts.
2016-02-01 00:00:00
mouse model
cell fate
isoxazole scaffold drive neuroendocrine phenotypes
Gene Expression
Neuroendocrine Phenotype
isoxazole compounds
support neuroendocrine
Isoxazole Alters Metabolites
lipotoxic conditions