%0 Journal Article %A Wang, Xiuyu %A Hou, Yi %A Yao, Li %A Gao, Mingyuan %A Ge, Maofa %D 2016 %T Generation, Characterization, and Application of Hierarchically Structured Self-Assembly Induced by the Combined Effect of Self-Emulsification and Phase Separation %U https://acs.figshare.com/articles/journal_contribution/Generation_Characterization_and_Application_of_Hierarchically_Structured_Self_Assembly_Induced_by_the_Combined_Effect_of_Self_Emulsification_and_Phase_Separation/2076742 %R 10.1021/jacs.5b12149.s001 %2 https://ndownloader.figshare.com/files/3708685 %K multifunctional properties %K MNP %K strategy %K phase separation %K image contrast enhancement %K Phase SeparationHierarchically %K container features %K MSHS %X Hierarchically structured magnetic single-hole hollow spheres (MSHS) have been successfully obtained via a facile self-assembly strategy. This methodology allows the double emulsions generated via the combined effect of self-emulsification and phase separation to provide confinement for directing the self-assembly of magnetic nanoparticles (MNPs). The resulting MSHS fully capitalize on both the multifunctional properties of MNPs and container features of single-hole hollow spheres. Moreover, the magnetic properties showed obvious improvement and can be tuned by modulating the assembled structure. Thus, MSHS can be used as a smart platform with multiple functionalities including image contrast enhancement, selective encapsulation for biomacromolecules, on-demand release, and magnetically guided transport. This strategy is very promising in the design of hierarchically structured assemblies for desired applications in biomedicine and other fields. %I ACS Publications