Detection of Critical Genes Associated with Overall Survival (OS) and Progression-Free Survival (PFS) in Reconstructed Canine B-Cell Lymphoma Gene Regulatory Network (GRN) Mohamad Zamani-Ahmadmahmudi Ali Najafi Seyed Mahdi Nassiri 10.6084/m9.figshare.2068245 https://tandf.figshare.com/articles/dataset/Detection_of_Critical_Genes_Associated_with_Overall_Survival_OS_and_Progression_Free_Survival_PFS_in_Reconstructed_Canine_B_Cell_Lymphoma_Gene_Regulatory_Network_GRN_/2068245 <p>Canine B-cell lymphoma GRN was reconstructed from gene expression data in the STRING and MiMI databases. Critical genes of networks were identified and correlations of critical genes with overall survival (OS) and progression-free survival (PFS) were evaluated. Significant changes were detected in the expressions of <i>GLUL, CD44, CD79A, ARF3, FOS, BLOC1S1, FYN, GZMB, GALNT3, IFI44, CD3G, GNG2, ESRP1</i>, and <i>CCND1</i> in the STRING network and of <i>PECAM1, GLUL, CD44, GDI1, E2F4, TLE1, CD79A, UCP2, CCND1, FYN, RHOQ, BIN1</i>, and <i>A2M</i> in the MiMI network. Final survival analysis highlighted <i>CCND1</i> and <i>FOS</i> as genes with significant correlations with OS and PFS.</p> 2016-01-28 11:15:23 Canine lymphoma Gene regulatory network (GRN) Critical genes Overall survival (OS) Progression-free survival (PFS)