Detection of Critical Genes Associated with Overall Survival (OS) and Progression-Free Survival (PFS) in Reconstructed Canine B-Cell Lymphoma Gene Regulatory Network (GRN)
Mohamad Zamani-Ahmadmahmudi
Ali Najafi
Seyed Mahdi Nassiri
10.6084/m9.figshare.2068245
https://tandf.figshare.com/articles/dataset/Detection_of_Critical_Genes_Associated_with_Overall_Survival_OS_and_Progression_Free_Survival_PFS_in_Reconstructed_Canine_B_Cell_Lymphoma_Gene_Regulatory_Network_GRN_/2068245
<p>Canine B-cell lymphoma GRN was reconstructed from gene expression data in the STRING and MiMI databases. Critical genes of networks were identified and correlations of critical genes with overall survival (OS) and progression-free survival (PFS) were evaluated. Significant changes were detected in the expressions of <i>GLUL, CD44, CD79A, ARF3, FOS, BLOC1S1, FYN, GZMB, GALNT3, IFI44, CD3G, GNG2, ESRP1</i>, and <i>CCND1</i> in the STRING network and of <i>PECAM1, GLUL, CD44, GDI1, E2F4, TLE1, CD79A, UCP2, CCND1, FYN, RHOQ, BIN1</i>, and <i>A2M</i> in the MiMI network. Final survival analysis highlighted <i>CCND1</i> and <i>FOS</i> as genes with significant correlations with OS and PFS.</p>
2016-01-28 11:15:23
Canine lymphoma
Gene regulatory network (GRN)
Critical genes
Overall survival (OS)
Progression-free survival (PFS)