10.6084/m9.figshare.2064336.v3 Antonia Wadley Antonia Wadley Peter Kamerman Peter Kamerman Constance Chew Constance Chew Zané Lombard Zané Lombard Catherine Cherry Catherine Cherry Patricia Price Patricia Price Post-print: A polymorphism in IL4 associates with sensory neuropathy in African HIV patients. DOI: 10.1016/j.molimm.2013.02.002 figshare 2017 HIV neuropathy neuropathic pain Africa IL-4 genetics Neuroscience Neurogenetics Neurology and Neuromuscular Diseases Genetics 2017-09-05 07:54:24 Journal contribution https://figshare.com/articles/journal_contribution/Post_print_copy_A_polymorphism_in_IL4_associates_with_sensory_neuropathy_in_African_HIV_patients_DOI_10_1016_j_molimm_2013_02_002/2064336 <p><b>Post-print copy of: </b>Wadley AL, Kamerman PR, Chew CSN, Lombard Z, Cherry CL, Price P. A polymorphism in IL4 associates with sensory neuropathy in African HIV patients. Molecular Immunology 55: 197-199, 2013. DOI: 10.1016/j.molimm.2013.02.002, PMID: 23511027</p><p><b>Abstract: </b>Animal and in vitro models of HIV-associated sensory neuropathy suggest an inflammatory etiology. Previous genetic association studies of HIV-SN have been in small Caucasian or Asian cohorts. We assessed cytokine single nucleotide polymorphisms (SNPs) in a Black Southern African cohort. 342 black HIV-positive Southern Africans were recruited. 190 individuals had HIV-associated sensory neuropathy and 152 did not. DNA samples from all participants were genotyped for cytokine SNPs identified in studies of HIV disease and/or neuropathy. IL4-590*T associated with an increased prevalence of HIV-SN including following correction for age, height and CD4 T-cell count. No other cytokine SNPs assessed displayed an association. We identified a novel association between IL4-590*T and HIV-SN in African HIV-positive patients which warrants further investigation.</p>