10.1371/journal.pone.0050559.g007 Maria T. Kuipers Maria T. Kuipers Hamid Aslami Hamid Aslami Alexander P. J. Vlaar Alexander P. J. Vlaar Nicole P. Juffermans Nicole P. Juffermans Anita M. Tuip-de Boer Anita M. Tuip-de Boer Maria A. Hegeman Maria A. Hegeman Geartsje Jongsma Geartsje Jongsma Joris J. T. H. Roelofs Joris J. T. H. Roelofs Tom van der Poll Tom van der Poll Marcus J. Schultz Marcus J. Schultz Catharina W. Wieland Catharina W. Wieland Allopurinol and uricase pre-treatment attenuate alveolar barrier dysfunction. Public Library of Science 2012 uricase pre-treatment attenuate alveolar 2012-11-30 00:55:31 Figure https://plos.figshare.com/articles/figure/_Allopurinol_and_uricase_pre_treatment_attenuate_alveolar_barrier_dysfunction_/203331 <p>Mice were pre-treated with vehicle (10% dimethylsulfoxide, dark grey bars), uricase (0.2 mg/kg, light grey, striped bars), or allopurinol (25 mg/kg (white bars) 1 hour before start of mechanical ventilation (VILI). Spontaneously breathing, vehicle pre-treated mice served as controls (C). After 5 hours mice were killed. Lung wet-to-dry ratio (<b>A</b>), total protein levels in lung lavage fluid (<b>B</b>) and immunoglobulin M (IgM) concentrations in (<b>C</b>) were analyzed. Data represent mean ± SEM of 4 control mice and n = 9 for the VILI groups (for IgM n = 5−6). ##P<0.01, ###P<0.001 vs. vehicle ventilated. ***p<0.001 vs. vehicle control.</p>