10.1371/journal.pone.0050559.g007
Maria T. Kuipers
Maria
T. Kuipers
Hamid Aslami
Hamid
Aslami
Alexander P. J. Vlaar
Alexander
P. J. Vlaar
Nicole P. Juffermans
Nicole
P. Juffermans
Anita M. Tuip-de Boer
Anita
M. Tuip-de Boer
Maria A. Hegeman
Maria
A. Hegeman
Geartsje Jongsma
Geartsje
Jongsma
Joris J. T. H. Roelofs
Joris
J. T. H. Roelofs
Tom van der Poll
Tom
van der Poll
Marcus J. Schultz
Marcus
J. Schultz
Catharina W. Wieland
Catharina
W. Wieland
Allopurinol and uricase pre-treatment attenuate alveolar barrier dysfunction.
Public Library of Science
2012
uricase
pre-treatment
attenuate
alveolar
2012-11-30 00:55:31
Figure
https://plos.figshare.com/articles/figure/_Allopurinol_and_uricase_pre_treatment_attenuate_alveolar_barrier_dysfunction_/203331
<p>Mice were pre-treated with vehicle (10% dimethylsulfoxide, dark grey bars), uricase (0.2 mg/kg, light grey, striped bars), or allopurinol (25 mg/kg (white bars) 1 hour before start of mechanical ventilation (VILI). Spontaneously breathing, vehicle pre-treated mice served as controls (C). After 5 hours mice were killed. Lung wet-to-dry ratio (<b>A</b>), total protein levels in lung lavage fluid (<b>B</b>) and immunoglobulin M (IgM) concentrations in (<b>C</b>) were analyzed. Data represent mean ± SEM of 4 control mice and n = 9 for the VILI groups (for IgM n = 5−6). ##P<0.01, ###P<0.001 vs. vehicle ventilated. ***p<0.001 vs. vehicle control.</p>