%0 DATA
%A Patrizia, Nanni
%A Valentina, Gatta
%A Laura, Menotti
%A Carla, De Giovanni
%A Marianna, Ianzano
%A Arianna, Palladini
%A Valentina, Grosso
%A Massimiliano, Dall'Ora
%A Stefania, Croci
%A Giordano, Nicoletti
%A Lorena, Landuzzi
%A Manuela, Iezzi
%A Gabriella, Campadelli-Fiume
%A Pier-Luigi, Lollini
%D 2013
%T Therapy with R-LM249 of systemic metastases induced by the i.v. injection of human breast carcinoma cell line MDA-MB-453.
%U https://plos.figshare.com/articles/_Therapy_with_R_LM249_of_systemic_metastases_induced_by_the_i_v_injection_of_human_breast_carcinoma_cell_line_MDA_MB_453_/168640
%R 10.1371/journal.ppat.1003155.g005
%2 https://ndownloader.figshare.com/files/498140
%K r-lm249
%K systemic
%K metastases
%K induced
%K injection
%K carcinoma
%X R-LM249 was administered i.p. at 10^{8} pfu dose (4 weekly injections) to groups of 9–10 Rag2^{−/−};Il2rg^{−/−} mice. (**A, C, E**) incidence of macroscopic metastases in the indicated organs, as determined at necropsy; (**B, D, F**) total metastatic burden (mean + SEM) in organs as quantified by human centromeric DNA qPCR. Statistical analysis of differences: panel **A**, p<0.0001 at Fisher's exact test; panel **B**, p = 0.0004 at both Student's *t* and non-parametric Wilcoxon rank sum tests; panel **C**, p = 0.07 at Fisher's exact test; panel **D**, p = 0.056 at Student's *t* test and p = 0.03 at non-parametric Wilcoxon rank sum test.