10.1371/journal.pntd.0004302.g002
Renato Sathler-Avelar
Renato
Sathler-Avelar
Danielle Marquete Vitelli-Avelar
Danielle
Marquete Vitelli-Avelar
Armanda Moreira Mattoso-Barbosa
Armanda
Moreira Mattoso-Barbosa
Marcelo Perdigão-de-Oliveira
Marcelo
Perdigão-de-Oliveira
Ronaldo Peres Costa
Ronaldo
Peres Costa
Silvana Maria Elói-Santos
Silvana
Maria Elói-Santos
Matheus de Souza Gomes
Matheus
de Souza Gomes
Laurence Rodrigues do Amaral
Laurence
Rodrigues do Amaral
Andréa Teixeira-Carvalho
Andréa
Teixeira-Carvalho
Olindo Assis Martins-Filho
Olindo
Assis Martins-Filho
Edward J. Dick Jr
Edward
J. Dick Jr
Gene B. Hubbard
Gene
B. Hubbard
Jane F. VandeBerg
Jane
F. VandeBerg
John L. VandeBerg
John
L. VandeBerg
Adaptive immunity features from cynomolgus macaques naturally infected with <i>T</i>. <i>cruzi</i> (CH) and non-infected controls (NI).
Public Library of Science
2016
Trypanosoma cruzi Resemble
Systems Biology Approaches
systems biology analysis
expression
Human Chagas Disease BackgroundCynomolgus macaques
ni
nk
15 cynomolgus macaques
Chagas disease
ch
Major Immunological Findings Observed
granzyme
imbricate biomarker networks
2016-01-28 12:41:27
Figure
https://plos.figshare.com/articles/figure/_Adaptive_immunity_features_from_cynomolgus_macaques_naturally_infected_with_T_cruzi_CH_and_non_infected_controls_NI_/1642031
<p>(A) The frequencies of CD3<sup>+</sup> lymphocytes and T-cell subsets (CD4<sup>+</sup> and CD8<sup>+</sup>), the expression of adhesion molecule (CD54) and activation status (CD69 and HLADR) were performed by multicolor flow cytometry. (B) The expression of cytotoxicity markers (Granzyme A, Granzyme B and Perforin) of CD8<sup>+</sup> T-cells was investigated by intracellular staining flow cytometry. (C) Analysis of B-cells, the activation status (CD69), and the expression of the regulatory FcγR (CD32) were evaluated by three-color flow cytometry. The results are expressed as mean percentage with standard error. Significant differences at <i>p<</i>0.05 are identified by (*).</p>