%0 Figure %A Dalla Rosa, Ilaria %A Cámara, Yolanda %A Durigon, Romina %A F. Moss, Chloe %A Vidoni, Sara %A Akman, Gokhan %A Hunt, Lilian %A Johnson, Mark A. %A Grocott, Sarah %A Wang, Liya %A R. Thorburn, David %A Hirano, Michio %A Poulton, Joanna %A W. Taylor, Robert %A Elgar, Greg %A Martí, Ramon %A Voshol, Peter %A J. Holt, Ian %A Spinazzola, Antonella %D 2016 %T Mpv17-/- mouse liver mitochondria have significantly reduced levels of two precursors of DNA synthesis, dGTP and dTTP. %U https://plos.figshare.com/articles/figure/_Mpv17_mouse_liver_mitochondria_have_significantly_reduced_levels_of_two_precursors_of_DNA_synthesis_dGTP_and_dTTP_/1637040 %R 10.1371/journal.pgen.1005779.g002 %2 https://ndownloader.figshare.com/files/2626720 %K dNTP levels %K Mitochondria MPV 17 %K mitochondrial DNA loss %K MPV 17 deficiency %K mitochondrial DNA depletion %K dysfunction causes mitochondrial DNA abnormalities %K MPV 17 Loss Causes Deoxynucleotide Insufficiency %K deoxynucleoside supplementation %K Slow DNA Replication %K mitochondrial deoxynucleotide homeostasis %K mitochondrial genomic instability %K DNA copy number %K MPV 17 disease models %X

The abundance of dNTPs was determined by means of an extension assay after extraction of nucleotides from liver (A), kidney (B) or brain (C) of Mpv17+/+ and Mpv17-/- mice (see Methods). All mice (n = 5) were sacrificed between 8 and 10 weeks of age. P values were obtained using Mann-Whitney test (* P<0.05, NS, not significant P>0.05).

%I PLOS Genetics