10.1371/journal.pone.0145985.g007 Takuya Sakamoto Takuya Sakamoto Shogo Kobayashi Shogo Kobayashi Daisaku Yamada Daisaku Yamada Hiroaki Nagano Hiroaki Nagano Akira Tomokuni Akira Tomokuni Yoshito Tomimaru Yoshito Tomimaru Takehiro Noda Takehiro Noda Kunihito Gotoh Kunihito Gotoh Tadafumi Asaoka Tadafumi Asaoka Hiroshi Wada Hiroshi Wada Koichi Kawamoto Koichi Kawamoto Shigeru Marubashi Shigeru Marubashi Hidetoshi Eguchi Hidetoshi Eguchi Yuichiro Doki Yuichiro Doki Masaki Mori Masaki Mori <i>In vivo</i> analysis of mice xenografted with MzChA-1 and MzChA-1_GR cells. Public Library of Science 2016 vorinostat SNAI Biliary Tract Cancer emt hdac BTC cell lines nod MzChA chemoresistance zeb cdh tgf Smad 4 mtt TFK 2016-01-05 14:56:12 Figure https://plos.figshare.com/articles/figure/_In_vivo_analysis_of_mice_xenografted_with_MzChA_1_and_MzChA_1_GR_cells_/1632485 <p>NOD/SCID mice xenografted with MzChA-1 and MzChA-1_GR cells were employed as <i>in vivo</i> models. When the tumor volume was over 200 mm<sup>3</sup>, the mice were treated with the indicated drugs (GEM [125 mg/kg, once a week] and/or vorinostat [60 mg/kg, 5 consecutive days per week]). The prognostic value was evaluated by the Kaplan–Meier method and a log-rank test. (A) Survival curve for mice xenografted with MzChA-1 cells. (B) Survival curve for mice xenografted with MzChA-1_GR cells. (C) Immunohistochemistry for SMAD4 on the resected tumor specimens of the mice xenografted with MzChA-1_GR cells.</p>