10.1371/journal.pone.0145985.g007
Takuya Sakamoto
Takuya
Sakamoto
Shogo Kobayashi
Shogo
Kobayashi
Daisaku Yamada
Daisaku
Yamada
Hiroaki Nagano
Hiroaki
Nagano
Akira Tomokuni
Akira
Tomokuni
Yoshito Tomimaru
Yoshito
Tomimaru
Takehiro Noda
Takehiro
Noda
Kunihito Gotoh
Kunihito
Gotoh
Tadafumi Asaoka
Tadafumi
Asaoka
Hiroshi Wada
Hiroshi
Wada
Koichi Kawamoto
Koichi
Kawamoto
Shigeru Marubashi
Shigeru
Marubashi
Hidetoshi Eguchi
Hidetoshi
Eguchi
Yuichiro Doki
Yuichiro
Doki
Masaki Mori
Masaki
Mori
<i>In vivo</i> analysis of mice xenografted with MzChA-1 and MzChA-1_GR cells.
Public Library of Science
2016
vorinostat
SNAI
Biliary Tract Cancer
emt
hdac
BTC cell lines
nod
MzChA
chemoresistance
zeb
cdh
tgf
Smad 4
mtt
TFK
2016-01-05 14:56:12
Figure
https://plos.figshare.com/articles/figure/_In_vivo_analysis_of_mice_xenografted_with_MzChA_1_and_MzChA_1_GR_cells_/1632485
<p>NOD/SCID mice xenografted with MzChA-1 and MzChA-1_GR cells were employed as <i>in vivo</i> models. When the tumor volume was over 200 mm<sup>3</sup>, the mice were treated with the indicated drugs (GEM [125 mg/kg, once a week] and/or vorinostat [60 mg/kg, 5 consecutive days per week]). The prognostic value was evaluated by the Kaplan–Meier method and a log-rank test. (A) Survival curve for mice xenografted with MzChA-1 cells. (B) Survival curve for mice xenografted with MzChA-1_GR cells. (C) Immunohistochemistry for SMAD4 on the resected tumor specimens of the mice xenografted with MzChA-1_GR cells.</p>