Shi, Wei L. Bain, Amanda Schwer, Bjoern Al-Ejeh, Fares Smith, Corey Wong, Lee Chai, Hua S. Miranda, Mariska Ho, Uda Kawaguchi, Makoto Miura, Yutaka W. Finnie, John Wall, Meaghan Heierhorst, Jörg Wicking, Carol Spring, Kevin J. W. Alt, Frederick Kum Khanna, Kum Conditional <i>Ssb1</i>-deleted mice are sensitive to IR. <p>(A) Schematic diagram of the radiation challenge assay in <i>Ssb1</i> deleted mice. <i>Rosa26</i>-CreER<sup>T2</sup>: <i>Ssb1</i><sup>+/+</sup>, <i>Rosa26</i>-CreER<sup>T2</sup>: <i>Ssb1</i><sup>+/−</sup> and <i>Rosa26</i>-CreER<sup>T2</sup>: <i>Ssb1</i><sup>−/−</sup> mice were challenged with 8 Gy of total body irradiation (TBI). The acute lethal response of mice to TBI was evaluated over a 30-day observation period. (B) Kaplan-Meier survival analysis of irradiated mice. Kaplan-Meier survival curves compared by log-rank (Mantel-Cox) analysis showed significant difference between <i>Rosa26</i>-CreER<sup>T2</sup>: <i>Ssb1</i><sup>−/−</sup> mice and the other two groups (**<i>P</i>&lt;0.01), while no difference was found between <i>Rosa26</i>-CreER<sup>T2</sup>: <i>Ssb1<sup>+/+</sup></i> and <i>Rosa26</i>-CreER<sup>T2</sup>: <i>Ssb1<sup>+/−</sup></i> groups. (C) Representative images of Haematoxylin and eosin, Ki67 (cell proliferation) and ApopTag (cell death) staining on small intestine sections from mice at Day 5 post 8 Gy of TBI.</p> mice 2013-02-07
    https://plos.figshare.com/articles/figure/Conditional_i_Ssb1_i_deleted_mice_are_sensitive_to_IR_/163044
10.1371/journal.pgen.1003298.g006