Schematic of nanoATV cellular uptake and tissue distribution. Andrea L. Martinez-Skinner Mariluz A. AraĆ­nga Pavan Puligujja Diana L. Palandri Hannah M. Baldridge Benson J. Edagwa JoEllyn M. McMillan R. Lee Mosley Howard E. Gendelman 10.1371/journal.pone.0145966.g008 https://plos.figshare.com/articles/figure/_Schematic_of_nanoATV_cellular_uptake_and_tissue_distribution_/1630209 <p>Balb/c mice are injected with nanoATV directly into the peritoneum. This leads to an inflammatory reaction in which primarily granulocytes are induced. The nanoparticles are taken up, principally by macrophages and to a lesser degree by granulocytes. These cells and unincorporated nanoparticles leave the blood to reach Kupffer cells in the liver, splenic macrophages and other phagocytes including those in lymph nodes. In tissue the macrophages encase and store the drug particles in endosomal compartments.</p> 2016-01-05 14:53:52 injection gr tissue macrophage distribution nanoART leukocyte cell subsets macrophage nanoATV response nanoATV tissue depots lymph nodes nanoformulated site secretory cell functions facs macrophage subcellular depots