Schematic of nanoATV cellular uptake and tissue distribution.
Andrea L. Martinez-Skinner
Mariluz A. AraĆnga
Pavan Puligujja
Diana L. Palandri
Hannah M. Baldridge
Benson J. Edagwa
JoEllyn M. McMillan
R. Lee Mosley
Howard E. Gendelman
10.1371/journal.pone.0145966.g008
https://plos.figshare.com/articles/figure/_Schematic_of_nanoATV_cellular_uptake_and_tissue_distribution_/1630209
<p>Balb/c mice are injected with nanoATV directly into the peritoneum. This leads to an inflammatory reaction in which primarily granulocytes are induced. The nanoparticles are taken up, principally by macrophages and to a lesser degree by granulocytes. These cells and unincorporated nanoparticles leave the blood to reach Kupffer cells in the liver, splenic macrophages and other phagocytes including those in lymph nodes. In tissue the macrophages encase and store the drug particles in endosomal compartments.</p>
2016-01-05 14:53:52
injection
gr
tissue macrophage distribution
nanoART
leukocyte cell subsets
macrophage nanoATV response
nanoATV tissue depots
lymph nodes
nanoformulated
site
secretory cell functions
facs
macrophage subcellular depots