TY - DATA T1 - Global miRNA Expression Profiling Identifies miR-1290 as Novel Potential oncomiR in Laryngeal Carcinoma PY - 2016/01/05 AU - Joanna Janiszewska AU - Marcin Szaumkessel AU - Magdalena Kostrzewska-Poczekaj AU - Kinga Bednarek AU - Julia Paczkowska AU - Joanna Jackowska AU - Reidar Grenman AU - Krzysztof Szyfter AU - Malgorzata Wierzbicka AU - Maciej Giefing AU - Malgorzata Jarmuz-Szymczak UR - https://plos.figshare.com/articles/dataset/_Global_miRNA_Expression_Profiling_Identifies_miR_1290_as_Novel_Potential_oncomiR_in_Laryngeal_Carcinoma_/1629174 DO - 10.1371/journal.pone.0144924 L4 - https://ndownloader.figshare.com/files/2615131 L4 - https://ndownloader.figshare.com/files/2615132 KW - miRNA expression KW - cell carcinoma KW - ITPR 2 KW - tumor controls.ResultsWithin KW - Laryngeal Carcinoma BackgroundLaryngeal KW - bioinformatical approach KW - 9 downregulated miRNA genes KW - tumor suppressor genes KW - neck cancers KW - LSCC pathogenesis KW - target genes KW - LSCC cell lines KW - 33 upregulated KW - target genes MAF N2 - BackgroundLaryngeal squamous cell carcinoma (LSCC) is the most common group among head and neck cancers. LSCC is characterized by a high incidence in Europe. With the aim of better understanding its genetic background we performed global miRNA expression profiling of LSCC cell lines and primary specimens. By this approach we identified a cohort of 33 upregulated and 9 downregulated miRNA genes in LSCC as compared to epithelial no tumor controls.ResultsWithin this group we identified overexpression of the novel miR-1290 gene not reported in the context of LSCC before. Using a combined bioinformatical approach in connection with functional analysis we delineated two putative target genes of miR-1290 namely ITPR2 and MAF which are significantly downregulated in LSCC. They are interesting candidates for tumor suppressor genes as they are implicated in apoptosis and other processes deregulated in cancer.ConclusionTaken together, we propose miR-1290 as the new oncomiR involved in LSCC pathogenesis. Additionally, we suggest that the oncogenic potential of miR-1290 might be expressed by the involvement in downregulation of its target genes MAF and ITPR2. ER -