Expression level of selected miRNA and selection scheme of miR-1290 target genes. Joanna Janiszewska Marcin Szaumkessel Magdalena Kostrzewska-Poczekaj Kinga Bednarek Julia Paczkowska Joanna Jackowska Reidar Grenman Krzysztof Szyfter Malgorzata Wierzbicka Maciej Giefing Malgorzata Jarmuz-Szymczak 10.1371/journal.pone.0144924.g001 https://plos.figshare.com/articles/figure/_Expression_level_of_selected_miRNA_and_selection_scheme_of_miR_1290_target_genes_/1629172 <p>A) Overexpression of miR-1290 and miR-1246 in primary LSCC cases (LNA real-time qPCR). B) Schematic presentation of the selection process of miR-1290 candidate genes. C) Expression level of <i>MAF</i>, <i>ITPR2</i> and <i>RGS5</i> in LSCC cell lines and no tumor controls (Affymetrix U133 plus 2.0) based on [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0144924#pone.0144924.ref020" target="_blank">20</a>]. * fold change in LSCC cell lines compared to no tumor controls. D) Expression level of <i>MAF</i> and <i>ITPR2</i> in 22 primary tumor samples compared to 5 no tumor controls.</p> 2016-01-05 14:52:54 miRNA expression cell carcinoma ITPR 2 tumor controls.ResultsWithin Laryngeal Carcinoma BackgroundLaryngeal bioinformatical approach 9 downregulated miRNA genes tumor suppressor genes neck cancers LSCC pathogenesis target genes LSCC cell lines 33 upregulated target genes MAF