K. Arthur, Greer Mark Duffy, S. M. Roach, Katy A. Hirst, Rob Shikotra, Aarti A. Gaillard, Erol Bradding, Peter Freshly isolated HBECs, and the H292 and BEAS-2B airway epithelial cell lines exhibit K<sub>Ca</sub>3.1 channel activity. <p>Current-voltage curves demonstrating that 100 μM 1-EBIO induced characteristic K<sub>Ca</sub>3.1 channel currents in freshly isolated HBECs isolated from (<b>A</b>) one patient with asthma (n = 3 cells) and (<b>B</b>) one healthy control (n = 3 cells). TRAM-34 (200 nM) blocked 1-EBIO-induced currents to near-baseline levels. Characteristic 1-EBIO-dependent K<sub>Ca</sub>3.1 channel activity, sensitive to TRAM-34, was also seen in (<b>C</b>) the H292 cell line (n = 6 cells) and (<b>D</b>) the BEAS-2B cell line (n = 8 cells).</p> KCa 3.1 blockade;KCa 3.1 ion currents;KCa 3.1 blockers;Primary HBECs;epithelial cell proliferation;tgf;epithelial fluid secretion;KCa 3.1 mRNA;HBEC function;KCa 3.1 currents;emt;H 292 cells;airway epithelial biology;Selective KCa 3.1 blockers;tram;Human Bronchial Epithelial Cells;neoplastic H 292 epithelial cell line;KCa 3.1 protein expression;ica;KCa 3.1 channel;beas;KCa 3.1 K 2015-12-23
    https://plos.figshare.com/articles/figure/_Freshly_isolated_HBECs_and_the_H292_and_BEAS_2B_airway_epithelial_cell_lines_exhibit_K_Ca_3_1_channel_activity_/1627513
10.1371/journal.pone.0145259.g003