Zhang, Chen Liu, Bing-Yu Zeng, Ke-Wu Guo, Xiao-Yu Jiang, Yong Tu, Peng-Fei New sesquiterpene and thiophene derivatives from <i>Artemisia rupestris</i> <div><p></p><p>A new sesquiterpene, rupestrisin A (<b>1</b>), and three new thiophene derivatives, rupestrienes A–C (<b>2</b>–<b>4</b>), were isolated from <i>Artemisia rupestris</i>. Their structures were determined by analyses of MS and NMR spectroscopic data, and the absolute configuration of <b>1</b> was established by calculated ECD spectra using time-dependent density functional theory. In <i>in vitro</i> bioassays, compounds <b>1</b>–<b>4</b> showed inhibitory effects on LPS-stimulated NO production in BV-2 microglial cells with IC<sub>50</sub> values of 24.3, 20.3, 8.5, and 5.3 μM, respectively.</p></div> density;compound;NMR spectroscopic data;bv;new;ecd;rupestriene;thiophene derivatives;bioassay;rupestrisin;Artemisia rupestris;microglial;analyses;configuration;IC 50 values;spectra;sesquiterpene;ms 2015-12-10
    https://tandf.figshare.com/articles/journal_contribution/New_sesquiterpene_and_thiophene_derivatives_from_i_Artemisia_rupestris_i_/1621908
10.6084/m9.figshare.1621908.v2