TY - DATA T1 - The emerging threat of artemisinin resistance in malaria: focus on artemether-lumefantrine PY - 2015/12/08 AU - Abdoulaye A Djimde AU - Kamal Hamed AU - Michael Makanga AU - Kelli Kuhen UR - https://tandf.figshare.com/articles/journal_contribution/The_emerging_threat_of_artemisinin_resistance_in_malaria_focus_on_artemether_lumefantrine/1620661 DO - 10.6084/m9.figshare.1620661.v1 L4 - https://ndownloader.figshare.com/files/2602834 KW - marker KW - artemisinin resistance KW - Greater Mekong Subregion KW - al KW - data KW - efficacy KW - threat KW - Plasmodium falciparum malaria N2 - The development of artemisinin resistance in the Greater Mekong Subregion poses a significant threat to malaria elimination. Artemisinin-based combination therapies including artemether-lumefantrine (AL) are recommended by WHO as first-line treatment for uncomplicated Plasmodium falciparum malaria. This article provides a comprehensive review of the existing and latest data as a basis for interpretation of observed variability in parasite sensitivity to AL over the last 5 years. Clinical efficacy and preclinical data from a range of endemic countries are summarized, including potential molecular markers of resistance. Overall, AL remains effective in the treatment of uncomplicated P. falciparum malaria in most regions. Establishing validated molecular markers for resistance and strict efficacy monitoring will reinforce timely updates of treatment policies. ER -