Zhang, Erli Guo, Qianyun Gao, Haiyang Xu, Ruixia Teng, Siyong Wu, Yongjian Effect of resveratrol and/or metformin on SIRT1-mediated signaling and senescent “memory” in HUVECs. <p>Immunoblotting and quantification of SIRT1 protein expression after (A-B) resveratrol treatment (RSV; 0, 1.25, 2.5, 5, or 10 μM) or (C-D) metformin treatment (MET; 0, 1, 10, 50, 100, 250 μM). Values were normalized to β-actin. (E-J) Immunoblotting and quantification of p300, SIRT1, p21, Ac-p53, and p53 protein expression after RSV (5 μM) or MET (50 μM) treatment. For p300, SIRT1, and p21, values were normalized to β-actin; for Ac-p53, normalized to total p53. (K) The deacetylase activity of SIRT1 in HUVECs treated with or without RSV (5 μM) or MET (50 μM). (L) The percentage of SA β-Gal positive cells in HUVECs treated with or without RSV (5 μM) or MET (50 μM). *<i>P</i> < 0.05.</p> rvs;SIRT 1 axis;SIRT 1;senescence;hn;ng;glucose;SIRT 1 activators;senescent;huvec;deacetylase SIRT 1;hg;3 days;rsv 2015-12-02
    https://plos.figshare.com/articles/figure/_Effect_of_resveratrol_and_or_metformin_on_SIRT1_mediated_signaling_and_senescent_8220_memory_8221_in_HUVECs_/1616948
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