N. Le, Sarah T. Porebski, Benjamin McCoey, Julia Fodor, James Riley, Blake Godlewska, Marlena Góra, Monika Czarnocka, Barbara Paul Banga, J E. Hoke, David Kass, Itamar M. Buckle, Ashley Mapping epitopes onto the cis TPO dimer. <p><b>(A)</b> Epitopes and residues identified in various studies as constituting immunodominant regions IDR-A (blue) and IDR-B (pink); <b>(B)</b> Lumen-facing side of MPO-like domain; <b>(C)</b> Close-up shows that much of the two immunodominant regions are on the lumen-facing surface of the MPO-like domain near the dimer interface, particularly IDR-B; <b>(D)</b> Membrane-facing side of TPO containing the heme (orange) cavity.</p> Autoantigenicity Thyroid peroxidase;TPO structure;Thyroid hormones;apical membrane;TPO dimer;dimer organisation;immunodominant regions;sequence features;20 years;surface regions;dimer interface;domain rearrangements;Oligomeric State;mpo;enzyme function;Epitope mapping studies;epitope fragmentation;modelling approach;steric hindrance;Thyroid Peroxidase 2015-12-01
    https://plos.figshare.com/articles/figure/_Mapping_epitopes_onto_the_cis_TPO_dimer_/1615848
10.1371/journal.pone.0142615.g004