%0 Figure %A N. Le, Sarah %A T. Porebski, Benjamin %A McCoey, Julia %A Fodor, James %A Riley, Blake %A Godlewska, Marlena %A Góra, Monika %A Czarnocka, Barbara %A Paul Banga, J %A E. Hoke, David %A Kass, Itamar %A M. Buckle, Ashley %D 2015 %T A comparison between membrane-embedded, dimeric models of TPO isoform1 in two different conformations. %U https://plos.figshare.com/articles/figure/_A_comparison_between_membrane_embedded_dimeric_models_of_TPO_isoform1_in_two_different_conformations_/1615846 %R 10.1371/journal.pone.0142615.g002 %2 https://ndownloader.figshare.com/files/2596514 %K Autoantigenicity Thyroid peroxidase %K TPO structure %K Thyroid hormones %K apical membrane %K TPO dimer %K dimer organisation %K immunodominant regions %K sequence features %K 20 years %K surface regions %K dimer interface %K domain rearrangements %K Oligomeric State %K mpo %K enzyme function %K Epitope mapping studies %K epitope fragmentation %K modelling approach %K steric hindrance %K Thyroid Peroxidase %X

(A) Schematic of trans model with active site facing away from follicular membrane. Coloring as in Fig 1; (B) Cis model with active site facing towards follicular membrane; (C) perpendicular views of trans model; (D) perpendicular views of cis model. TPO represented as cartoon and space filling (subunits A and B, respectively) for clarity. Domains are coloured as follows: MPO-like domain (green), CCP-like domain (Shamrock green), EGF-like domain (cyan-blue), and TM domain (dark-blue). Catalytic heme represented as red spheres, and DMPC molecules represented as lines and coloured as CPK.

%I PLOS ONE