10.1371/journal.pone.0142615.g002
Sarah N. Le
Sarah
N. Le
Benjamin T. Porebski
Benjamin
T. Porebski
Julia McCoey
Julia
McCoey
James Fodor
James
Fodor
Blake Riley
Blake
Riley
Marlena Godlewska
Marlena
Godlewska
Monika Góra
Monika
Góra
Barbara Czarnocka
Barbara
Czarnocka
J Paul Banga
J
Paul Banga
David E. Hoke
David
E. Hoke
Itamar Kass
Itamar
Kass
Ashley M. Buckle
Ashley
M. Buckle
A comparison between membrane-embedded, dimeric models of TPO isoform1 in two different conformations.
Public Library of Science
2015
Autoantigenicity Thyroid peroxidase
TPO structure
Thyroid hormones
apical membrane
TPO dimer
dimer organisation
immunodominant regions
sequence features
20 years
surface regions
dimer interface
domain rearrangements
Oligomeric State
mpo
enzyme function
Epitope mapping studies
epitope fragmentation
modelling approach
steric hindrance
Thyroid Peroxidase
2015-12-01 16:01:29
Figure
https://plos.figshare.com/articles/figure/_A_comparison_between_membrane_embedded_dimeric_models_of_TPO_isoform1_in_two_different_conformations_/1615846
<p><b>(A)</b> Schematic of trans model with active site facing away from follicular membrane. Coloring as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0142615#pone.0142615.g001" target="_blank">Fig 1</a>; <b>(B)</b> Cis model with active site facing towards follicular membrane; <b>(C)</b> perpendicular views of trans model; <b>(D)</b> perpendicular views of cis model. TPO represented as cartoon and space filling (subunits A and B, respectively) for clarity. Domains are coloured as follows: MPO-like domain (green), CCP-like domain (Shamrock green), EGF-like domain (cyan-blue), and TM domain (dark-blue). Catalytic heme represented as red spheres, and DMPC molecules represented as lines and coloured as CPK.</p>