10.1371/journal.pone.0142615.g002 Sarah N. Le Sarah N. Le Benjamin T. Porebski Benjamin T. Porebski Julia McCoey Julia McCoey James Fodor James Fodor Blake Riley Blake Riley Marlena Godlewska Marlena Godlewska Monika Góra Monika Góra Barbara Czarnocka Barbara Czarnocka J Paul Banga J Paul Banga David E. Hoke David E. Hoke Itamar Kass Itamar Kass Ashley M. Buckle Ashley M. Buckle A comparison between membrane-embedded, dimeric models of TPO isoform1 in two different conformations. Public Library of Science 2015 Autoantigenicity Thyroid peroxidase TPO structure Thyroid hormones apical membrane TPO dimer dimer organisation immunodominant regions sequence features 20 years surface regions dimer interface domain rearrangements Oligomeric State mpo enzyme function Epitope mapping studies epitope fragmentation modelling approach steric hindrance Thyroid Peroxidase 2015-12-01 16:01:29 Figure https://plos.figshare.com/articles/figure/_A_comparison_between_membrane_embedded_dimeric_models_of_TPO_isoform1_in_two_different_conformations_/1615846 <p><b>(A)</b> Schematic of trans model with active site facing away from follicular membrane. Coloring as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0142615#pone.0142615.g001" target="_blank">Fig 1</a>; <b>(B)</b> Cis model with active site facing towards follicular membrane; <b>(C)</b> perpendicular views of trans model; <b>(D)</b> perpendicular views of cis model. TPO represented as cartoon and space filling (subunits A and B, respectively) for clarity. Domains are coloured as follows: MPO-like domain (green), CCP-like domain (Shamrock green), EGF-like domain (cyan-blue), and TM domain (dark-blue). Catalytic heme represented as red spheres, and DMPC molecules represented as lines and coloured as CPK.</p>