Hypoxia results in adaptive resistance to the anti-proliferative effects of metformin.
Takla Griss
Emma E. Vincent
Robert Egnatchik
Jocelyn Chen
Eric H. Ma
Brandon Faubert
Benoit Viollet
Ralph J. DeBerardinis
Russell G. Jones
10.1371/journal.pbio.1002309.g007
https://plos.figshare.com/articles/figure/_Hypoxia_results_in_adaptive_resistance_to_the_anti_proliferative_effects_of_metformin_/1615844
<p><b>A</b>. Proliferation of 143B<i>wt</i> cells cultured in the absence or presence of 5 mM metformin under normoxic (white) or hypoxic (black, 1% O<sub>2</sub>) conditions. Growth curves over time are indicated. <b>B.</b> Proliferation of 143B<i>wt</i> cells cultured under normoxia (white) or hypoxia (black, 1% O<sub>2</sub>) in medium containing the indicated doses of metformin. Cell numbers were determined after 72 h of treatment, and are expressed relative to cell counts in control conditions. Each data point represents the mean ± SEM for each condition (<i>n</i> = 10), and is representative of three independent experiments. Raw data for this figure can be found in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1002309#pbio.1002309.s007" target="_blank">S7 Data</a>.</p>
2015-12-01 15:56:00
metformin arrests cancer cell proliferation
lipid biosynthesis
tumor cell resistance
LKB
tca
ampk
etc
Metformin Antagonizes Cancer Cell Proliferation
cancer cell proliferation
antagonizes cancer cell growth
type II diabetes
mitochondrial electron transport chain