Hypoxia results in adaptive resistance to the anti-proliferative effects of metformin. Takla Griss Emma E. Vincent Robert Egnatchik Jocelyn Chen Eric H. Ma Brandon Faubert Benoit Viollet Ralph J. DeBerardinis Russell G. Jones 10.1371/journal.pbio.1002309.g007 https://plos.figshare.com/articles/figure/_Hypoxia_results_in_adaptive_resistance_to_the_anti_proliferative_effects_of_metformin_/1615844 <p><b>A</b>. Proliferation of 143B<i>wt</i> cells cultured in the absence or presence of 5 mM metformin under normoxic (white) or hypoxic (black, 1% O<sub>2</sub>) conditions. Growth curves over time are indicated. <b>B.</b> Proliferation of 143B<i>wt</i> cells cultured under normoxia (white) or hypoxia (black, 1% O<sub>2</sub>) in medium containing the indicated doses of metformin. Cell numbers were determined after 72 h of treatment, and are expressed relative to cell counts in control conditions. Each data point represents the mean ± SEM for each condition (<i>n</i> = 10), and is representative of three independent experiments. Raw data for this figure can be found in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1002309#pbio.1002309.s007" target="_blank">S7 Data</a>.</p> 2015-12-01 15:56:00 metformin arrests cancer cell proliferation lipid biosynthesis tumor cell resistance LKB tca ampk etc Metformin Antagonizes Cancer Cell Proliferation cancer cell proliferation antagonizes cancer cell growth type II diabetes mitochondrial electron transport chain