RMSF of the A-loop region and IC<sub>50</sub> values of imatinib for the studied tyrosine kinases and the designed triple mutants of Src. Silvia Lovera Maria Morando Encarna Pucheta-Martinez Jorge L. Martinez-Torrecuadrada Giorgio Saladino Francesco L. Gervasio 10.1371/journal.pcbi.1004578.t001 https://plos.figshare.com/articles/dataset/_RMSF_of_the_A_loop_region_and_IC_50_values_of_imatinib_for_the_studied_tyrosine_kinases_and_the_designed_triple_mutants_of_Src_/1612626 <p>RMSF of the A-loop region and IC<sub>50</sub> values of imatinib for the studied tyrosine kinases and the designed triple mutants of Src.</p> 2015-11-25 03:24:58 binding kinetics mutation imatinib resistance Kinase Conformational Dynamics T 315I gatekeeper Drug Resistance cancer patients tyrosine kinases ABL kinase domain dynamics simulations Myeloid leukemia microcalorimetry experiments DFG motif energy calculations binding mechanism energy landscape