%0 Journal Article %A Yu, Yan %A Zhao, Miao %A Yu, Lili %A Pan, Xiaohong %A Wu, Lingling %D 2015 %T Immunotoxic effect of arsenic trioxide on Caenorhabditis elegans %U https://tandf.figshare.com/articles/journal_contribution/Immunotoxic_effect_of_arsenic_trioxide_on_i_Caenorhabditis_elegans_i_/1608055 %R 10.6084/m9.figshare.1608055.v1 %2 https://ndownloader.figshare.com/files/2446790 %K Arsenic Trioxide %K molt %K Survival %K elegan %K 2O exposure %X

A Pseudomonas aeruginosaCaenorhabditis elegans pathogenesis model was utilized to assess immunotoxic effects of arsenic trioxide (As2O3). After 2 h of As2O3 exposure, 500 µmol L−1 and 1 mmol L−1 As2O3 treatment significantly decreased median survivals of C. elegans (10 h after L4/adult molt). However, 2 h of As2O3 exposure caused no significant changes in the survivals rates of C. elegans (2 h after L4/adult molt). Notably, a significant dose-related immunoenhancement was observed in C. elegans (2 h after L4/adult molt) after 12 h of arsenite exposure.

%I Taylor & Francis