B. Bazan, Silvia Costa, Tania A. Frank de Araújo, Eliseu Feriotti, Claudia V. Loures, Flávio D. Pretel, Fernando L. G. Calich, Vera In the absence of Tregs, mice show exacerbated inflammatory responses. <p>(A) Photomicrographs of lungs, livers and spleens from Rag1<sup>-/-</sup> mice infected with Pb18 after adoptive cell transfer of Treg, CD4<sup>+</sup>Foxp3<sup>-</sup> T cells and Treg + CD4<sup>+</sup>Foxp3<sup>-</sup> T cells. Organ sections were stained with H&E and Grocott and examined under a light microscope with a magnification of 100×. Morphometric analysis of lesions in lungs, livers and spleens from Rag1<sup>-/-</sup> mice after 6 weeks of infection with Pb18. (B) Areas of lesions were quantified from photomicrographs of organ sections. Data represent the mean ± SD from three experiments (n ≥ 5; *<i>p</i> < 0.05; ** <i>p</i> < 0.005; ***<i>p</i> < 0.001; ND = not detectable).</p> 3GFP;impairing T cell immunity;Treg cells;T Cell Immunity;tissue inflammation;pcm;regulatory t cells;106 yeast cells;Dual Role Exerted;Pulmonary Paracoccidioidomycosis Paracoccidioidomycosis;limit pathogen growth;T cell subsets 2015-10-29
    https://plos.figshare.com/articles/figure/_In_the_absence_of_Tregs_mice_show_exacerbated_inflammatory_responses_/1589256
10.1371/journal.pntd.0004189.g007