%0 Figure %A B. Bazan, Silvia %A Costa, Tania A. %A Frank de Araújo, Eliseu %A Feriotti, Claudia %A V. Loures, Flávio %A D. Pretel, Fernando %A L. G. Calich, Vera %D 2015 %T In the absence of Tregs, mice show exacerbated inflammatory responses. %U https://plos.figshare.com/articles/figure/_In_the_absence_of_Tregs_mice_show_exacerbated_inflammatory_responses_/1589256 %R 10.1371/journal.pntd.0004189.g007 %2 https://ndownloader.figshare.com/files/2389040 %K 3GFP %K impairing T cell immunity %K Treg cells %K T Cell Immunity %K tissue inflammation %K pcm %K regulatory t cells %K 106 yeast cells %K Dual Role Exerted %K Pulmonary Paracoccidioidomycosis Paracoccidioidomycosis %K limit pathogen growth %K T cell subsets %X

(A) Photomicrographs of lungs, livers and spleens from Rag1-/- mice infected with Pb18 after adoptive cell transfer of Treg, CD4+Foxp3- T cells and Treg + CD4+Foxp3- T cells. Organ sections were stained with H&E and Grocott and examined under a light microscope with a magnification of 100×. Morphometric analysis of lesions in lungs, livers and spleens from Rag1-/- mice after 6 weeks of infection with Pb18. (B) Areas of lesions were quantified from photomicrographs of organ sections. Data represent the mean ± SD from three experiments (n ≥ 5; *p < 0.05; ** p < 0.005; ***p < 0.001; ND = not detectable).

%I PLOS Neglected Tropical Diseases