In the absence of Tregs, mice show exacerbated inflammatory responses.
Silvia B. Bazan
Tania A. Costa
Eliseu Frank de Araújo
Claudia Feriotti
Flávio V. Loures
Fernando D. Pretel
Vera L. G. Calich
10.1371/journal.pntd.0004189.g007
https://plos.figshare.com/articles/figure/_In_the_absence_of_Tregs_mice_show_exacerbated_inflammatory_responses_/1589256
<p>(A) Photomicrographs of lungs, livers and spleens from Rag1<sup>-/-</sup> mice infected with Pb18 after adoptive cell transfer of Treg, CD4<sup>+</sup>Foxp3<sup>-</sup> T cells and Treg + CD4<sup>+</sup>Foxp3<sup>-</sup> T cells. Organ sections were stained with H&E and Grocott and examined under a light microscope with a magnification of 100×. Morphometric analysis of lesions in lungs, livers and spleens from Rag1<sup>-/-</sup> mice after 6 weeks of infection with Pb18. (B) Areas of lesions were quantified from photomicrographs of organ sections. Data represent the mean ± SD from three experiments (n ≥ 5; *<i>p</i> < 0.05; ** <i>p</i> < 0.005; ***<i>p</i> < 0.001; ND = not detectable).</p>
2015-10-29 03:23:37
3GFP
impairing T cell immunity
Treg cells
T Cell Immunity
tissue inflammation
pcm
regulatory t cells
106 yeast cells
Dual Role Exerted
Pulmonary Paracoccidioidomycosis Paracoccidioidomycosis
limit pathogen growth
T cell subsets