Ablation of Treg cell leads to decreased fungal loads and diminished dissemination.
Silvia B. Bazan
Tania A. Costa
Eliseu Frank de Araújo
Claudia Feriotti
Flávio V. Loures
Fernando D. Pretel
Vera L. G. Calich
10.1371/journal.pntd.0004189.g003
https://plos.figshare.com/articles/figure/_Ablation_of_Treg_cell_leads_to_decreased_fungal_loads_and_diminished_dissemination_/1589252
<p>(A) Groups of five C57BL/6Foxp3<sup>GFP</sup> mice were given anti-CD25 or control IgG antibodies and inoculated with 10<sup>6</sup><i>P</i>. <i>brasiliensis</i> yeast cells. The frequency of lung-derived CD4<sup>+</sup>CD25<sup>+</sup> cells at weeks 2 and 10 post-infection is indicated. (B) Frequency and number of conventional CD4<sup>+</sup> T cells as well as of Treg cells in the lungs at weeks 2 and 10 after infection following administration of control IgG or anti-CD25 antibody. Bars represent mean ± SD of three independent experiments with four to six mice per group (** <i>p</i> < 0.005; *** <i>p</i> < 0.001). (C) Fungal burden in organs of mice infected with Pb18 and treated with anti-CD25 or control IgG, after 2 (left) and 10 (right) weeks of infection. Horizontal bars indicate the mean value in each group (**<i>p</i> < 0.05, ***<i>p</i> < 0.005; n ≥ 15).</p>
2015-10-29 03:23:37
3GFP
impairing T cell immunity
Treg cells
T Cell Immunity
tissue inflammation
pcm
regulatory t cells
106 yeast cells
Dual Role Exerted
Pulmonary Paracoccidioidomycosis Paracoccidioidomycosis
limit pathogen growth
T cell subsets