Ablation of Treg cell leads to decreased fungal loads and diminished dissemination. Silvia B. Bazan Tania A. Costa Eliseu Frank de Araújo Claudia Feriotti Flávio V. Loures Fernando D. Pretel Vera L. G. Calich 10.1371/journal.pntd.0004189.g003 https://plos.figshare.com/articles/figure/_Ablation_of_Treg_cell_leads_to_decreased_fungal_loads_and_diminished_dissemination_/1589252 <p>(A) Groups of five C57BL/6Foxp3<sup>GFP</sup> mice were given anti-CD25 or control IgG antibodies and inoculated with 10<sup>6</sup><i>P</i>. <i>brasiliensis</i> yeast cells. The frequency of lung-derived CD4<sup>+</sup>CD25<sup>+</sup> cells at weeks 2 and 10 post-infection is indicated. (B) Frequency and number of conventional CD4<sup>+</sup> T cells as well as of Treg cells in the lungs at weeks 2 and 10 after infection following administration of control IgG or anti-CD25 antibody. Bars represent mean ± SD of three independent experiments with four to six mice per group (** <i>p</i> < 0.005; *** <i>p</i> < 0.001). (C) Fungal burden in organs of mice infected with Pb18 and treated with anti-CD25 or control IgG, after 2 (left) and 10 (right) weeks of infection. Horizontal bars indicate the mean value in each group (**<i>p</i> < 0.05, ***<i>p</i> < 0.005; n ≥ 15).</p> 2015-10-29 03:23:37 3GFP impairing T cell immunity Treg cells T Cell Immunity tissue inflammation pcm regulatory t cells 106 yeast cells Dual Role Exerted Pulmonary Paracoccidioidomycosis Paracoccidioidomycosis limit pathogen growth T cell subsets