10.1371/journal.pbio.1002279.g010 Ileana Soto Ileana Soto Leah C. Graham Leah C. Graham Hannah J. Richter Hannah J. Richter Stephen N. Simeone Stephen N. Simeone Jake E. Radell Jake E. Radell Weronika Grabowska Weronika Grabowska W. Keith Funkhouser W. Keith Funkhouser Megan C. Howell Megan C. Howell Gareth R. Howell Gareth R. Howell APOE is a contributor to exercise-induced preservation of neurovascular integrity. Public Library of Science 2015 microglia complement component C 1QA complement activation Complement Induction Aging apoe exercise resolution histological analyses Aging Neurovascular Dysfunction Neurodegenerative diseases basement membrane reduction neurovascular structures decline astrocytic Apoe 2015-10-29 03:22:53 Figure https://plos.figshare.com/articles/figure/_APOE_is_a_contributor_to_exercise_induced_preservation_of_neurovascular_integrity_/1589247 <p>(A and B) Voluntary running does not change vascular and extravascular deposition of FIBRIN (red) in aged <i>Apoe</i><sup><i>-/-</i></sup> mice. Endothelial cells (cyan) are immunolabeled with CD31. (C and D) PDGFRβ<sup>+</sup> pericyte number (magenta) but not coverage, is only partially increased in aged Rn <i>Apoe</i><sup><i>-/-</i></sup> mice compared to controls. (E and F) The number of IBA1<sup>+</sup> microglia/monocytes (green) is not reduced by running in aged <i>Apoe</i><sup><i>-/-</i></sup> mice. Values in (B, D, and F) are mean <u>+</u> SEM, (B) <i>n =</i> 6 and (E–G) <i>n =</i> 3–4 per group. In (D) <i>**p</i> = 0.0024, <i>*p</i> = 0.0468, <i>*p</i> = 0.0166, and <i>*p</i> = 0.0430, and in (F) **<i>p</i> = 0.0022 and 0.0084, and *<i>p</i> = 0.0105 by ANOVA followed by Tukey’s posthoc tests. Scale Bars: 50 μm. The data used to make this figure can be found in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1002279#pbio.1002279.s001" target="_blank">S1 Dataset</a>.</p>