10.1371/journal.pbio.1002279.g010
Ileana Soto
Ileana
Soto
Leah C. Graham
Leah
C. Graham
Hannah J. Richter
Hannah
J. Richter
Stephen N. Simeone
Stephen
N. Simeone
Jake E. Radell
Jake
E. Radell
Weronika Grabowska
Weronika
Grabowska
W. Keith Funkhouser
W.
Keith Funkhouser
Megan C. Howell
Megan
C. Howell
Gareth R. Howell
Gareth
R. Howell
APOE is a contributor to exercise-induced preservation of neurovascular integrity.
Public Library of Science
2015
microglia
complement component C 1QA
complement activation
Complement Induction Aging
apoe
exercise
resolution histological analyses
Aging Neurovascular Dysfunction
Neurodegenerative diseases
basement membrane reduction
neurovascular structures decline
astrocytic Apoe
2015-10-29 03:22:53
Figure
https://plos.figshare.com/articles/figure/_APOE_is_a_contributor_to_exercise_induced_preservation_of_neurovascular_integrity_/1589247
<p>(A and B) Voluntary running does not change vascular and extravascular deposition of FIBRIN (red) in aged <i>Apoe</i><sup><i>-/-</i></sup> mice. Endothelial cells (cyan) are immunolabeled with CD31. (C and D) PDGFRβ<sup>+</sup> pericyte number (magenta) but not coverage, is only partially increased in aged Rn <i>Apoe</i><sup><i>-/-</i></sup> mice compared to controls. (E and F) The number of IBA1<sup>+</sup> microglia/monocytes (green) is not reduced by running in aged <i>Apoe</i><sup><i>-/-</i></sup> mice. Values in (B, D, and F) are mean <u>+</u> SEM, (B) <i>n =</i> 6 and (E–G) <i>n =</i> 3–4 per group. In (D) <i>**p</i> = 0.0024, <i>*p</i> = 0.0468, <i>*p</i> = 0.0166, and <i>*p</i> = 0.0430, and in (F) **<i>p</i> = 0.0022 and 0.0084, and *<i>p</i> = 0.0105 by ANOVA followed by Tukey’s posthoc tests. Scale Bars: 50 μm. The data used to make this figure can be found in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1002279#pbio.1002279.s001" target="_blank">S1 Dataset</a>.</p>