TY - DATA T1 - Exercise preserves neurovascular unit integrity in aged mice. PY - 2015/10/29 AU - Ileana Soto AU - Leah C. Graham AU - Hannah J. Richter AU - Stephen N. Simeone AU - Jake E. Radell AU - Weronika Grabowska AU - W. Keith Funkhouser AU - Megan C. Howell AU - Gareth R. Howell UR - https://plos.figshare.com/articles/figure/_Exercise_preserves_neurovascular_unit_integrity_in_aged_mice_/1589240 DO - 10.1371/journal.pbio.1002279.g006 L4 - https://ndownloader.figshare.com/files/2389006 KW - microglia KW - complement component C 1QA KW - complement activation KW - Complement Induction Aging KW - apoe KW - exercise KW - resolution histological analyses KW - Aging Neurovascular Dysfunction KW - Neurodegenerative diseases KW - basement membrane reduction KW - neurovascular structures decline KW - astrocytic Apoe N2 - (A–B) Age-related intravascular and extravascular deposition of FIBRIN (red) is significantly reduced in aged runner mice. Microvessels are immunostained with endothelial CD31 (cyan). (C) PDGFRβ+ pericyte (magenta) number and coverage are significantly increased in aged runners when compared with aged sedentary mice. (D) Quantitative analysis of PDGFRβ+ pericytes number and coverage. (E) AQP4 (blue) immunoreactivity of astrocyte endfeet is significantly increased in aged runners when compared with aged sedentary mice. (F) AQP4 protein levels show a significant preservation of both parameters on aged runner mice. In panels (D–F), values are mean + SEM, n = 4 aging mice, n = 6 aged Sd mice and n = 6 aged Rn mice. In (B) *p = 0.014 and (F) *p = 0.0318 by unpaired t test. In (D) ****p < 0.0001 and ***p = 0.0014 by ANOVA followed by Tukey’s posthoc tests. Scale Bars: 50 μm. The data used to make this figure can be found in S1 Dataset. ER -