Immunohistochemical labeling for thrombospondin 1. Harry A. Quigley Ian F. Pitha Derek S. Welsbie Cathy Nguyen Matthew R. Steinhart Thao D. Nguyen Mary Ellen Pease Ericka N. Oglesby Cynthia A. Berlinicke Katherine L. Mitchell Jessica Kim Joan J. Jefferys Elizabeth C. Kimball 10.1371/journal.pone.0141137.g008 https://plos.figshare.com/articles/figure/_Immunohistochemical_labeling_for_thrombospondin_1_/1586593 <p>Immunostaining for thrombospondin-1 shows mild scleral label (arrowheads) in water-treated fellow eye (A) and dramatically increased label in both sclera and retina of water-glaucoma eye (B). Thrombospondin 1 label was less in sclera and retina of both the losartan fellow eye (C) and losartan-glaucoma eye than the corresponding water controls (D, scale bar = 50μm; DAPI counterstain).</p> 2015-10-27 03:50:48 IOP.ConclusionsThe neuroprotective effect tail cuff device transcription polymerase chain reaction RGC loss angiotensin receptors 3 day IOP elevations control glaucoma eyes scleral thickness regression model p enalapril blood pressure Experimental Glaucoma PurposeTo Alters Scleral Remodeling CD 1 mice Losartan Treatment Protects Retinal Ganglion Cells losartan treatment decreases Axonal transport blockade