10.6084/m9.figshare.1569665.v1
Havva Serap Toru
Havva
Serap Toru
Cem Yasar Sanhal
Cem
Yasar Sanhal
İnanç Mendilcioğlu
İnanç
Mendilcioğlu
Fatma Şeyda Karaveli
Fatma
Şeyda Karaveli
Özlem Ceren Uzun
Özlem
Ceren Uzun
Guzide Ayse Ocak
Guzide
Ayse Ocak
Associated anomalies with neural tube defects in fetal autopsies
Taylor & Francis Group
2015
January 2006
tube defects
anomaly
risk factors
ntd
tube closure
June 2012.
Associated anomalies
autopsies Neural tube defects
outcome counseling
primer abnormality
schisis association
Akdeniz University Pathology Department
pathology report
band syndrome
2015-03-24 00:00:00
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Associated_anomalies_with_neural_tube_defects_in_fetal_autopsies/1569665
<div><p></p><p>Neural tube defects (NTD), the consequences of aberrant neural tube closure during embryogenesis, have been mostly investigated in terms of their high prevalence, rate of mortalities and serious morbidities. A proper prenatal outcome counseling of couples coming across a fetal anomaly necessitates the detection and categorization of the primer abnormality, all the co-existing malformations. The aim of this work is to study the incidence and relevance of associated malformations in order to offer a complete pathology report with a true diagnosis. In this study, among 542 fetal autopsy 62 (%11.4) cases with NTD was recorded by the Akdeniz University Pathology Department between January 2006 and June 2012. Twenty (32.4%) NTD cases were associated with anomaly. Twelve cases of associated groups consisted of a congenital syndrome/association, spondylothoracic dysplasia, amniotic band syndrome, Meckel–Gruber syndrome, schisis association. The frequency of associated NTD was 32%, this result was higher than previous reports. NTDs have a significant genetic component to their etiology that interacts with environmental risk factors, which might pose Turkey to be a country with high prevalence of NTD. We want to emphasize that intensive screening, documentation of co-existent abnormalities of NTD, should be conducted in order to exhibit certain diagnosis, to perform proper prenatal genetic counseling of parents for on-going/future pregnancies.</p></div>