Kabirifard, Hassan Ghahremani, Samira Afsharpoor, Anita A simple and versatile protocol for the preparation of functionalized heterocycles utilizing 4-benzoyl-5-phenylamino-2,3-dihydrothiophene-2,3-dione <div><p>The reaction of ethyl benzoylpyruvate with phenyl isothiocyanate in alkaline medium yields 4-benzoyl-5-phenylamino-2,3-dihydrothiophene-2,3-dione (<b>1</b>). Reaction of the intermediate <b>1</b> with primary aromatic amines such as aniline derivatives, benzidine and secondary aliphatic amines, namely diethylamine, piperidine, morpholine and piperazine afforded the corresponding thiophene <b>2a–2g</b> and amide <b>3a–3d</b> derivatives. Compound <b>1</b> reacts with <i>N,N</i>′- and <i>N,O</i>-dinucleophiles such as 1,2-diaminoalkanes, 2-aminoethanol, 1-aminoguanidine, guanidine, urea, 1,2-phenylenediamine and 2-amino-4-methylphenol to form the heterocylic compounds <b>4–10</b>.</p></div> phenylenediamine;urea;guanidine;piperidine;aliphatic amines;morpholine;phenyl isothiocyanate;benzidine;medium;compound;piperazine;aminoguanidine;compound 1;yield;diethylamine;preparation;ethyl benzoylpyruvate;functionalized heterocycles;heterocylic;thiophene 2;diaminoalkane;amide 3;aniline derivatives;aminoethanol 2015-08-15
    https://tandf.figshare.com/articles/dataset/A_simple_and_versatile_protocol_for_the_preparation_of_functionalized_heterocycles_utilizing_4_benzoyl_5_phenylamino_2_3_dihydrothiophene_2_3_dione/1569280
10.6084/m9.figshare.1569280.v1