TY - DATA T1 - Effect of platelet receptor gene polymorphisms on outcomes in ST-elevation myocardial infarction patients after percutaneous coronary intervention PY - 2015/04/22 AU - Jing Wang AU - Yi Yao AU - Yin Zhang AU - Bo Xu AU - Run-Lin Gao AU - Lei Song AU - Zhan Gao AU - Jue Chen AU - Yuan Wu AU - Yue-Jin Yang AU - Jia-Hui Zhang AU - Xiao-Fang Tang AU - Yuan-Liang Ma AU - Xian-Min Meng AU - Jin-Qing Yuan UR - https://tandf.figshare.com/articles/journal_contribution/Effect_of_platelet_receptor_gene_polymorphisms_on_outcomes_in_ST_elevation_myocardial_infarction_patients_after_percutaneous_coronary_intervention/1568603 DO - 10.6084/m9.figshare.1568603.v1 L4 - https://ndownloader.figshare.com/files/2350583 KW - par KW - allele KW - gp KW - STEMI patients KW - bleeding KW - pci KW - 12 months KW - ligase detection reaction KW - ivs KW - gpvi KW - hr KW - ci KW - platelet receptors KW - ischemic events KW - multivariate Cox regression analysis KW - ITGA KW - platelet receptor genes KW - 2Y KW - F 2R rs 168753 KW - platelet receptor gene polymorphisms KW - genes encoding platelet receptors KW - P 2RY rs 6809699 KW - 483 STEMI patients N2 - Polymorphisms in platelet receptor genes may influence platelet function. This study aimed to assess the impact of five polymorphisms of genes encoding platelet receptors on the risk of ischemic and bleeding events in ST-elevation myocardial infarction (STEMI) patients after percutaneous coronary intervention (PCI). 503 consecutive Chinese patients with STEMI after an uneventful PCI and exposed to standard dual antiplatelet therapy for 12 months were enrolled. Polymorphisms of platelet receptors, GPIa (ITGA2, 807C > T, rs1126643), GPVI (GP6, 13254T > C, rs1613662), PAR-1 (F2R, IVS-14A > T, rs168753) and P2Y12 (P2RY12, 34C > T, rs6785930 and H1/H2 haplotype, 52G > T, rs6809699) were detected by the ligase detection reaction. The follow-up period was 12 months. Overall, 34 (6.8%) ischemic events occurred and 46 (9.1%) major bleedings occurred. Multivariate Cox regression analysis showed the carriage of F2R rs168753 minor allele was an independent predictor of the composite ischemic events (HR 0.387, 95% CI 0.193–0.778, p = 0.008) after adjusted for established risk factors. Multivariate logistic regression model identified that carriage of P2RY12 rs6809699 minor allele (OR 2.71, 95% CI 1.298–5.659, p = 0.008) was an independent predictor of major bleedings. The associations were then validated in a second cohort of 483 STEMI patients. In STEMI patients after PCI, F2R rs168753 minor allele could significantly contribute to the risk of ischemic events, and P2RY12 rs6809699 minor allele could predict bleedings. The genetic testing of platelet receptors can be valuable in predicting adverse events in STEMI patients after PCI. ER -