10.6084/m9.figshare.1568462.v1
Francesca Scazzocchio
Francesca
Scazzocchio
Stefania Garzoli
Stefania
Garzoli
Cinzia Conti
Cinzia
Conti
Claudia Leone
Claudia
Leone
Clio Renaioli
Clio
Renaioli
Federico Pepi
Federico
Pepi
Letizia Angiolella
Letizia
Angiolella
Properties and limits of some essential oils: chemical characterisation, antimicrobial activity, interaction with antibiotics and cytotoxicity
Taylor & Francis Group
2015
Bacteria
fungi
essential oils–antibiotic interaction
fluconazole
gentamicin
2015-09-22 00:00:00
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Properties_and_limits_of_some_essential_oils_chemical_characterisation_antimicrobial_activity_interaction_with_antibiotics_and_cytotoxicity/1568462
<p>Because of the emergence of multi-drug resistance bacteria and fungi, alternatives to conventional antimicrobial therapy are needed. This study aims to evaluate <i>in vitro</i> the antimicrobial activity of: <i>Mirtus communis</i>, <i>Coriandrum sativum</i>, <i>Pelargonium capitatum</i>, <i>Cuminum cyminum</i>, <i>Ocimum basilicum</i>, <i>Citrus aurantium amara</i>, <i>Cymbopogon. winterianus</i>, <i>Cymbopogon martini</i>, <i>Salvia sclarea</i>, <i>Melaleuca alternifolia</i> and <i>Mentha suaveolens</i> essential oils on bacteria and fungi, in relation to their chemical composition. The potential interaction of <i>M. alternifolia</i> (TTO), <i>C. sativum</i> (CDO) and <i>M. suaveolens</i> (EOMS) essential oils when used in combination with gentamicin and fluconazole has been evaluated. The results obtained showed a synergic effect on some bacteria and fungi, with FICI values ≤5. The cytotoxicity of TTO, CDO and EOMS was investigated towards HeLa cells. Only EOMS did not result cytotoxic at the active concentrations on micro-organisms. Further studies are necessary to obtain optimal ratios and dosing regimens for higher therapeutic efficacy and to decrease toxicological profiles.</p>