10.1371/journal.pgen.1005505.g005
Trevor L. Cameron
Trevor
L. Cameron
Katrina M. Bell
Katrina
M. Bell
Irma L. Gresshoff
Irma
L. Gresshoff
Lisa Sampurno
Lisa
Sampurno
Lorna Mullan
Lorna
Mullan
Joerg Ermann
Joerg
Ermann
Laurie H. Glimcher
Laurie
H. Glimcher
Raymond P. Boot-Handford
Raymond
P. Boot-Handford
John F. Bateman
John F.
Bateman
Microarray analysis of mutant and wildtype hypertrophic zones.
Public Library of Science
2015
Disease Schmid metaphyseal chondrodysplasia
canonical ER stress sensors
XBP
exogenous misfolding protein
chop
perk
hypertrophic zone collagen
GADD
chondrocyte differentiation
hypertrophic chondrocytes
upr
atf
Col 10a Mouse models phenocopying MCDS
pathology
ColXN 617K
growth plate cartilage hypertrophic zone expansion
hypertrophic zone cartilage
hypertrophic zone expansion
ire
runx
2015-09-15 03:14:21
Figure
https://plos.figshare.com/articles/figure/_Microarray_analysis_of_mutant_and_wildtype_hypertrophic_zones_/1545163
<p><i>(A)</i> Venn diagram depicting the relationship between probes indicating differential gene expression (fold difference ≥ 2.0, adjusted <i>p</i> value ≤ 0.01) following comparisons of <i>C/X</i> versus wildtype (<i>Wt</i>) (blue), <i>Xbp1</i><sup><i>CartΔEx2</i></sup> versus <i>Wt</i> (yellow), and <i>ColX</i><sup><i>N617K</i></sup> versus <i>Wt</i> (red), by whole genome microarray analysis of hypertrophic zone aRNA. <i>(B-D)</i> Ontological analysis of <i>(B)</i> all probes in cohort <i>i</i> in <i>(A)</i>, or those showing <i>(C)</i> up-regulation or <i>(D)</i> down-regulation, by Functional Annotation Clustering, using DAVID v6.7 software, and depicting representative gene ontology terms from each annotation cluster achieving an enrichment score (ES) ≥ 1.3.</p>