10.1371/journal.pgen.1005505.g005 Trevor L. Cameron Trevor L. Cameron Katrina M. Bell Katrina M. Bell Irma L. Gresshoff Irma L. Gresshoff Lisa Sampurno Lisa Sampurno Lorna Mullan Lorna Mullan Joerg Ermann Joerg Ermann Laurie H. Glimcher Laurie H. Glimcher Raymond P. Boot-Handford Raymond P. Boot-Handford John F. Bateman John F. Bateman Microarray analysis of mutant and wildtype hypertrophic zones. Public Library of Science 2015 Disease Schmid metaphyseal chondrodysplasia canonical ER stress sensors XBP exogenous misfolding protein chop perk hypertrophic zone collagen GADD chondrocyte differentiation hypertrophic chondrocytes upr atf Col 10a Mouse models phenocopying MCDS pathology ColXN 617K growth plate cartilage hypertrophic zone expansion hypertrophic zone cartilage hypertrophic zone expansion ire runx 2015-09-15 03:14:21 Figure https://plos.figshare.com/articles/figure/_Microarray_analysis_of_mutant_and_wildtype_hypertrophic_zones_/1545163 <p><i>(A)</i> Venn diagram depicting the relationship between probes indicating differential gene expression (fold difference ≥ 2.0, adjusted <i>p</i> value ≤ 0.01) following comparisons of <i>C/X</i> versus wildtype (<i>Wt</i>) (blue), <i>Xbp1</i><sup><i>CartΔEx2</i></sup> versus <i>Wt</i> (yellow), and <i>ColX</i><sup><i>N617K</i></sup> versus <i>Wt</i> (red), by whole genome microarray analysis of hypertrophic zone aRNA. <i>(B-D)</i> Ontological analysis of <i>(B)</i> all probes in cohort <i>i</i> in <i>(A)</i>, or those showing <i>(C)</i> up-regulation or <i>(D)</i> down-regulation, by Functional Annotation Clustering, using DAVID v6.7 software, and depicting representative gene ontology terms from each annotation cluster achieving an enrichment score (ES) ≥ 1.3.</p>