Henao-Tamayo, Marcela A. Shanley, Crystal Verma, Deepshikha Zilavy, Andrew C. Stapleton, Margaret K. Furney, Synthia Podell, Brendan Orme, Ian M. Representative histology images demonstrating leukocyte composition and necrosis in 923-infected mice. <p>[A] Large areas of pulmonary necrosis (arrowheads) developed in mice sham-vaccinated and infected with the 923 clinical strain, consisting of high numbers of degenerate neutrophils with destruction of adjacent airways (arrow). [B] Protection from progressive pulmonary pathology was afforded by BCG vaccination, with development of lymphocyte-rich lesions (arrows) and a complete absence of necrosis. [C] Neutrophil-dominated inflammation and necrosis in a mouse immunized with rBCG 422 (arrows). The degree of inflammation is less severe than in sham-immunized controls.</p> vaccine trial disqualifies;dose aerosol infection models;laboratory strains H 37Rv;BCG Pasteur;Western Cape region;Mycobacterium tuberculosis;trial site area;term survival assay;Western Cape strains;generation BCG vaccines 2015-09-14
    https://plos.figshare.com/articles/figure/_Representative_histology_images_demonstrating_leukocyte_composition_and_necrosis_in_923_infected_mice_/1541989
10.1371/journal.pone.0136500.g003