10.1371/journal.pgen.1005400.g002
Riddhita Chakraborty
Riddhita
Chakraborty
Ying Li
Ying
Li
Lei Zhou
Lei
Zhou
Kent G. Golic
Kent
G. Golic
Overexpression of <i>corp</i><sup><i>+</i></sup> suppresses the BARTL phenotype.
Public Library of Science
2015
p 53 mutants
Mdm 2
Drosophila P 53.
p 53.
P 53 transcriptionally activates corp
Drosophila melanogaster
Drosophila Corp shares
dna
Negative Feedback Loop
Drosophila gene companion
p 53 protein level
tumor suppressor p 53
Corp Regulates P 53
2015-07-31 03:16:21
Figure
https://plos.figshare.com/articles/figure/_Overexpression_of_corp_suppresses_the_BARTL_phenotype_/1499574
<p>(A) The range of eye phenotypes observed in the assay. The <i>B</i><sup><i>S</i></sup> phenotype of <i>H1</i> control males is shown at the left. When FLP is expressed (<i>ey>FLP</i>), the phenotypes can range from headless pharates (category 1) to adults with a fully developed wildtype eye (category 5). The distribution produced (B) in control males; (C) in males carrying <i>P{EPgy2}EY03495</i>, referred to as <i>EP-corp</i><sup><i>+</i></sup>; (D) by inclusion of a <i>UAS-corp</i><sup><i>+</i></sup> transgene; (E) with RNAi-mediated knockdown of <i>corp</i>; (F) in <i>corp</i><sup><i>95B</i></sup> mutants; (G) with rescue of the <i>corp</i><sup><i>95B</i></sup> phenotype by expression from the <i>UAS-corp</i><sup><i>+</i></sup> transgene; and, (H) with RNAi-mediated knockdown of <i>CG1632</i>. N represents number of eyes scored for each genotype. Each <i>P</i> value represents comparison with the wildtype control, shown in B. Genotypes were: (B) <i>y w/H1; eyGal4 UAS-FLP/+</i>; (C) <i>y w EP-corp</i><sup><i>+</i></sup><i>/H1; eyGal4 UAS-FLP/+</i>; (D) <i>y w/H1; eyGal4 UAS-FLP/+; UAS-corp</i><sup><i>+</i></sup><i>/+</i>; (E) <i>y w/H1; eyGal4 UAS-FLP/RNAi-corp</i>; (F) <i>y w corp</i><sup><i>95B</i></sup><i>/H1; eyGal4 UAS-FLP/+</i>; (G) <i>y w corp</i><sup><i>95B</i></sup><i>/H1; eyGal4 UAS-FLP/+; UAS-corp</i><sup><i>+</i></sup><i>/+</i>; (H) <i>y w/H1; eyGal4 UAS-FLP/RNAi-CG1632</i>.</p>