10.1371/journal.pgen.1005400.g001 Riddhita Chakraborty Riddhita Chakraborty Ying Li Ying Li Lei Zhou Lei Zhou Kent G. Golic Kent G. Golic The <i>DcY(H1)</i> chromosome and BARTL assay. Public Library of Science 2015 p 53 mutants Mdm 2 Drosophila P 53. p 53. P 53 transcriptionally activates corp Drosophila melanogaster Drosophila Corp shares dna Negative Feedback Loop Drosophila gene companion p 53 protein level tumor suppressor p 53 Corp Regulates P 53 2015-07-31 03:16:21 Figure https://plos.figshare.com/articles/figure/_The_DcY_H1_chromosome_and_BARTL_assay_/1499570 <p>Chromosome breakage and telomere loss in the BARTL assay. The <i>DcY(H1)</i> chromosome (drawn as sister chromatids in G2) is a <i>Y</i> chromosome that carries <i>y</i><sup><i>+</i></sup> on the short arm and dominant <i>B</i><sup><i>S</i></sup> on the long arm. Inverted <i>FRTs</i> are inserted proximal to <i>B</i><sup><i>S</i></sup>. The centromere is represented as a solid black circle, the telomeres as green rectangles, <i>B</i><sup><i>S</i></sup> gene as a red rectangle and inverted <i>FRTs</i> as half-arrows. When FLP mediates unequal sister chromatid exchange between inverted <i>FRT</i>s a dicentric and an acentric chromosome are produced. In the subsequent mitotic anaphase the dicentric chromosome is pulled to opposite poles and usually breaks. Each daughter cell receives a chromosome with a single broken end and one or both daughter cells lose the <i>B</i><sup><i>S</i></sup>-containing acentric fragment.</p>