%0 Figure %A Jalbrzikowski, Maria %A T. Lazaro, Maria %A Gao, Fuying %A Huang, Alden %A Chow, Carolyn %A H. Geschwind, Daniel %A Coppola, Giovanni %A E. Bearden, Carrie %D 2015 %T Network construction of co-expressed genes in relation to psychosis and autism spectrum disorders in 22q11DS. %U https://plos.figshare.com/articles/figure/_Network_construction_of_co_expressed_genes_in_relation_to_psychosis_and_autism_spectrum_disorders_in_22q11DS_/1491718 %R 10.1371/journal.pone.0132542.g004 %2 https://ndownloader.figshare.com/files/2186506 %K idiopathic psychosis %K expression changes %K antipsychotic medication use %K risk factors %K 22 q 11.2 Deletion Syndrome %K response pathways %K WGCNA analyses %K ht %K transcriptional regulation %K idiopathic ASD.ConclusionThese findings %K Functional Pathways Related %K brain tissue %K 22 q 11DS patients %K gene %K idiopathic schizophrenia %K 22 q 11DS %K peripheral blood %K deletion characteristics %K 22 q 11DS individuals %K pathways dysregulated %K 22 q 11DS carriers %K module %K Transcriptome Profiling %K 3 Mb deletion %K data mining techniques %K deletion breakpoints %K de %K Genomic Analyses %K phenotypic variation %K aCGH array %K spectrum disorders %K transcriptional changes %X

A) Dendogram of modules identified through Weighted Gene Co-expression Analysis, created through linkage hierarchical clustering of genes. B) Module-Trait relationships for age, gender, psychotic disorder diagnosis, autism spectrum disorder diagnosis, and positive symptoms, as measured by the SIPs. Numbers shown represent Pearson correlations between the modules and traits. P-values are in parentheses. Numbers on the color bar refer to the strength of the correlation in the table (red = 1, green = -1).

%I PLOS ONE