10.1371/journal.pone.0132542.g002
Maria Jalbrzikowski
Maria
Jalbrzikowski
Maria T. Lazaro
Maria
T. Lazaro
Fuying Gao
Fuying
Gao
Alden Huang
Alden
Huang
Carolyn Chow
Carolyn
Chow
Daniel H. Geschwind
Daniel
H. Geschwind
Giovanni Coppola
Giovanni
Coppola
Carrie E. Bearden
Carrie
E. Bearden
Differential expression (DE) analysis comparing controls to 22q11DS patients.
Public Library of Science
2015
idiopathic psychosis
expression changes
antipsychotic medication use
risk factors
22 q 11.2 Deletion Syndrome
response pathways
WGCNA analyses
ht
transcriptional regulation
idiopathic ASD.ConclusionThese findings
Functional Pathways Related
brain tissue
22 q 11DS patients
gene
idiopathic schizophrenia
22 q 11DS
peripheral blood
deletion characteristics
22 q 11DS individuals
pathways dysregulated
22 q 11DS carriers
module
Transcriptome Profiling
3 Mb deletion
data mining techniques
deletion breakpoints
de
Genomic Analyses
phenotypic variation
aCGH array
spectrum disorders
transcriptional changes
2015-07-22 03:02:56
Figure
https://plos.figshare.com/articles/figure/_Differential_expression_DE_analysis_comparing_controls_to_22q11DS_patients_/1491715
<p>A) Number of DE genes at <i>p</i><0.005. Four hundred probes (245 down-regulated, 155 up-regulated) were DE in 22q11DS vs. controls. B) Gene ontology analysis (<i>q≤</i>.05) of DE genes in 22q11DS vs. controls. Top categories included ensheathment of neurons, and regulation of cellular proliferation, signal transduction, and cell communication. Bars represent the–Log of the over-representation <i>q-</i>value. Red and green represent the proportion of up and down-regulated genes, respectively. C) Heat map depicting fold changes in peripheral blood samples for each 22q11DS participant. Genes are in rows and samples are in columns. Shades of red indicate up-regulation compared to the control condition, shades of green indicate down-regulation. D) Ingenuity pathway analysis results of a top network associated with significantly DE genes (p < .005) in 22q11DS vs. controls. This network is associated with cellular development, and cellular growth and proliferation. According to IPA, 10 different molecules in this network are associated with axon guidance signaling, including genes <i>MTORC1</i>, <i>GNB1L</i> and <i>PDGFA</i>, which were all down-regulated in 22q11DS patients.</p>