Baltic cyanobacteria – a source of biologically active compounds
Agnieszka Felczykowska
Prabha Devi
Päivi Tammela
Anna Mikosik
Sylwia Bloch
Bożena Nejman-Faleńczyk
Hanna Mazur-Marzec
Agata Błaszczyk
Natalia Hohlfeld
Justyna Kobos
Anna Toruńska-Sitarz
Sofia Montalvão
Lisette D’souza
Grzegorz Węgrzyn
10.6084/m9.figshare.1489797.v1
https://tandf.figshare.com/articles/journal_contribution/Baltic_cyanobacteria_8211_a_source_of_biologically_active_compounds/1489797
<div><p>Cyanobacteria are effective producers of bioactive metabolites, including both acute toxins and potential pharmaceuticals. In the current work, the biological activity of 27 strains of Baltic cyanobacteria representing different taxonomic groups and chemotypes were tested in a wide variety of assays. The cyanobacteria showed strain-specific differences in the induced effects. The extracts from <i>Nodularia spumigena</i> CCNP1401 were active in the highest number of tests, including protease and phosphatase inhibition assays. Four strains from Nostocales and four from Oscillatoriales increased proliferation of mitogen-stimulated human T cells. In antimicrobial assays, <i>Phormidium</i> sp. CCNP1317 (Oscillatoriales) strongly inhibited the growth of six fouling Gammaproteobacteria. The growth of monocotyl <i>Sorghum saccharatum</i> was inhibited by both toxin-producing and ‘non-toxic’ strains. The Baltic cyanobacteria were also found to be a rich source of commercially important enzymes. Among the 19 enzymatic activities tested, alkaline phosphatase, acid phosphatase, esterase (C4 and C8), and naphthol-AS-BI-phosphohydrolase were particularly common. In the cyanobacterial extracts, different peptides which may have been responsible for the observed effects were identified using LC-MS/MS. Their structures were classified to microcystins, nodularins, anabaenopeptins, cyanopeptolins, aeruginosins, spumigins and nostocyclopeptides.</p></div>
2015-07-03 00:00:00
source
extract
strain
Baltic cyanobacteria
Nodularia spumigena CCNP 1401
monocotyl Sorghum saccharatum
Oscillatoriale
phosphatase inhibition assays