Baltic cyanobacteria – a source of biologically active compounds Agnieszka Felczykowska Prabha Devi Päivi Tammela Anna Mikosik Sylwia Bloch Bożena Nejman-Faleńczyk Hanna Mazur-Marzec Agata Błaszczyk Natalia Hohlfeld Justyna Kobos Anna Toruńska-Sitarz Sofia Montalvão Lisette D’souza Grzegorz Węgrzyn 10.6084/m9.figshare.1489797.v1 https://tandf.figshare.com/articles/journal_contribution/Baltic_cyanobacteria_8211_a_source_of_biologically_active_compounds/1489797 <div><p>Cyanobacteria are effective producers of bioactive metabolites, including both acute toxins and potential pharmaceuticals. In the current work, the biological activity of 27 strains of Baltic cyanobacteria representing different taxonomic groups and chemotypes were tested in a wide variety of assays. The cyanobacteria showed strain-specific differences in the induced effects. The extracts from <i>Nodularia spumigena</i> CCNP1401 were active in the highest number of tests, including protease and phosphatase inhibition assays. Four strains from Nostocales and four from Oscillatoriales increased proliferation of mitogen-stimulated human T cells. In antimicrobial assays, <i>Phormidium</i> sp. CCNP1317 (Oscillatoriales) strongly inhibited the growth of six fouling Gammaproteobacteria. The growth of monocotyl <i>Sorghum saccharatum</i> was inhibited by both toxin-producing and ‘non-toxic’ strains. The Baltic cyanobacteria were also found to be a rich source of commercially important enzymes. Among the 19 enzymatic activities tested, alkaline phosphatase, acid phosphatase, esterase (C4 and C8), and naphthol-AS-BI-phosphohydrolase were particularly common. In the cyanobacterial extracts, different peptides which may have been responsible for the observed effects were identified using LC-MS/MS. Their structures were classified to microcystins, nodularins, anabaenopeptins, cyanopeptolins, aeruginosins, spumigins and nostocyclopeptides.</p></div> 2015-07-03 00:00:00 source extract strain Baltic cyanobacteria Nodularia spumigena CCNP 1401 monocotyl Sorghum saccharatum Oscillatoriale phosphatase inhibition assays