10.1371/journal.pone.0008541 Slavica Pecioska Slavica Pecioska M. Carola Zillikens M. Carola Zillikens Peter Henneman Peter Henneman Pieter J. Snijders Pieter J. Snijders Ben A. Oostra Ben A. Oostra Cornelia M. van Duijn Cornelia M. van Duijn Yurii S. Aulchenko Yurii S. Aulchenko Association between Type 2 Diabetes Loci and Measures of Fatness Public Library of Science 2010 loci measures fatness 2010-01-01 01:25:56 Dataset https://plos.figshare.com/articles/dataset/Association_between_Type_2_Diabetes_Loci_and_Measures_of_Fatness/145156 <div><h3>Background</h3><p>Type 2 diabetes (T2D) is a metabolic disorder characterized by disturbances of carbohydrate, fat and protein metabolism and insulin resistance. The majority of T2D patients are obese and obesity by itself may be a cause of insulin resistance. Our aim was to evaluate whether the recently identified T2D risk alleles are associated with human measures of fatness as characterized with Dual Energy X-ray Absorptiometry (DEXA).</p><h3>Methodology/Principal Findings</h3><p>Genotypes and phenotypes of approximately 3,000 participants from cross-sectional ERF study were analyzed. Nine single nucleotide polymorphisms (SNPs) in <em>CDKN2AB</em>, <em>CDKAL1</em>, <em>FTO</em>, <em>HHEX</em>, <em>IGF2BP2</em>, <em>KCNJ11</em>, <em>PPARG</em>, <em>SLC30A8</em> and <em>TCF7L2</em> were genotyped. We used linear regression to study association between individual SNPs and the combined allelic risk score with body mass index (BMI), fat mass index (FMI), fat percentage (FAT), waist circumference (WC) and waist to hip ratio (WHR). Significant association was observed between rs8050136 (<em>FTO</em>) and BMI (<em>p</em> = 0.003), FMI (<em>p</em> = 0.007) and WC (<em>p</em> = 0.03); fat percentage was borderline significant (<em>p</em> = 0.053). No other SNPs alone or combined in a risk score demonstrated significant association to the measures of fatness.</p><h3>Conclusions/Significance</h3><p>From the recently identified T2D risk variants only the risk variant of the <em>FTO</em> gene (rs8050136) showed statistically significant association with BMI, FMI, and WC.</p></div>